Document Detail

Factors that influence the ability to perform autologous priming.
MedLine Citation:
PMID:  18389664     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine which factors impact the ability to perform autologous priming (AP) of the extracorporeal circuit. Second, the effects of differential AP on transfusion and volume requirements were evaluated. After institutional review board approval, demographic, operative, volumetric, and transfusion data were prospectively collected on 100 adult patients undergoing cardiopulmonary bypass (CPB). Two analyses were conducted: AP Taken and percent AP Given. For each analysis, three groups were created based on standard distribution. Group A included patients within less than mean--1 SD (< or = 500 mL AP Taken or > or = 90% AP Given back), group B included patients within mean +/- 1 SD (501-1299 mL AP Taken or 11%-89% AP Given back), and group C included patients greater than mean + 1 SD (> or = 1300 mL AP Taken or < or = 10% AP given back). Weight, pre-CPB hematocrit, clinical severity, and pre-CPB volume balance did not differ between the groups. Significant differences existed in AP Taken and percent AP Given between individual perfusionists. More AP was given back with higher urine output (group A: 846 +/- 700 mL, group B: 613 +/- 414 mL, group C: 384 +/- 272 mL; p = .004), more autotransfusion [group A: 0 (0,1300 mL), group B: 0 (0,500 mL), group C: 0 (0,250 mL); p = .008], and less AP Taken [group A: 800 (0,1300 mL), group B: 1000 (200,1600 mL), group C: 1000 (800,1600 mL); p = .001]. When more AP was taken, CPB hematocrit was higher (group A: 22.3% +/- 4.8%, group B: 25.6% +/- 4.7%, group C: 26.6% +/- 4.3%; p = .032), and fewer patients received red blood cells (group A: 64.3%, group B: 28.3%, group C:14.3%; p = .017). Some perfusionists were able to remove more AP before CPB. When more AP was taken, CPB hematocrit was higher, fewer patients received a transfusion, and less AP was given back. More AP was also given back with higher urine output and higher blood loss to the autotransfusion device.
Cody Trowbridge; Alfred Stammers; Myra Klayman; Nicholas Brindisi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of extra-corporeal technology     Volume:  40     ISSN:  0022-1058     ISO Abbreviation:  J Extra Corpor Technol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-04-07     Completed Date:  2008-04-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267637     Medline TA:  J Extra Corpor Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  43-51     Citation Subset:  T    
Geisinger Medical Center, Perfusion Services 20-15, 100 N. Academy Avenue, Danville, PA 17821, USA.
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MeSH Terms
Blood Transfusion
Cardiopulmonary Bypass / instrumentation,  methods*
Extracorporeal Membrane Oxygenation / instrumentation*,  methods
Middle Aged
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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