Document Detail

Factors that determine recovery of left ventricular function after thrombolysis in patients with acute myocardial infarction.
MedLine Citation:
PMID:  3995707     Owner:  NLM     Status:  MEDLINE    
The coronary and ventricular angiograms of 47 patients with acute myocardial infarction in whom reperfusion was achieved by intracoronary streptokinase were quantitatively analyzed to determine the factors that affect recovery of regional left ventricular function after reperfusion. Hypokinesis in the infarct region was measured by the centerline method and expressed in terms of standard deviations (SDs) from normal. Severity of coronary artery stenosis was measured quantitatively. Hypokinesis showed more significant improvement after thrombolysis in patients with minimum stenosis diameter of greater than 0.4 mm than in those with severe residual stenosis, i.e., stenosis producing a minimum diameter of 0.4 mm or less (1.0 +/- 1.3 SD/chord, n = 31, vs 0.0 +/- 0.9 SD/chord, n = 7; p less than .05). Improvement in hypokinesis was greater in patients who received thrombolytic therapy within 2 hr than in those treated later (2.1 +/- 1.1, n = 8, vs 0.7 +/- 1.0 SD/chord, n = 28; p less than .001). These results indicate that angiographic reperfusion alone may not be sufficient: reperfusion must provide adequate flow and be achieved early to salvage myocardial function.
F H Sheehan; D G Mathey; J Schofer; H T Dodge; E L Bolson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  71     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-16     Completed Date:  1985-07-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1121-8     Citation Subset:  AIM; IM    
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MeSH Terms
Fibrinolytic Agents / therapeutic use*
Heart Function Tests
Heart Ventricles / physiopathology
Middle Aged
Myocardial Infarction / drug therapy*,  pathology,  physiopathology
Streptokinase / therapeutic use
Time Factors
Grant Support
Reg. No./Substance:
0/Fibrinolytic Agents; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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