Document Detail

Factors that affect pulse wave time transmission in the monitoring of cardiovascular system.
MedLine Citation:
PMID:  18350369     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Vascular transit time (VTT) can be defined as the first heart sound of the phonocardiography (PCG) signal to its arrival at the photoplethysmography (PPG). Studies have shown that monitoring VTT can be useful as an early prognosis of cardiac diseases. However, there is limited study conducted to understand the physiologic factors that affect VTT at the upper limb. In this study, the effect associated with difference in subject height, weight, heart rate, mean arterial pressure, systolic and diastolic blood pressure was assessed. METHODS: A study population of 31 healthy Chinese young adults (21 male; age range 20-33 yr) were recruited. PCG and PPG were recorded non-invasively from the fourth costal cartilage at the midclavicular line and right index finger, respectively. A single sample Kolmogorov-Smirnov (K-S) goodness-of-fit hypothesis test, a univariate linear regression analysis, and a multiple linear regression modelling were performed on the VTT measurements and the associated physiologic parameters. RESULTS: The results from the K-S test showed that the physiologic parameters and VTT measurements had a normal cumulative distribution function. Furthermore, all physiologic parameters were significantly and independently related to VTT (P < 0.05). Based on these physiological parameters, a VTT regression model was also derived (r (2) = 0.79). CONCLUSIONS: The findings herein suggest that the observed physiologic parameters have significant contributions to the nominal VTT value of a subject. Unlike pulse transit time, the VTT technique has the added advantage that the left ventricular isometric contraction time is not included in the timing derivation.
Jong Yong A Foo; Stephen J Wilson; Ping Wang
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Publication Detail:
Type:  Journal Article     Date:  2008-03-19
Journal Detail:
Title:  Journal of clinical monitoring and computing     Volume:  22     ISSN:  1387-1307     ISO Abbreviation:  J Clin Monit Comput     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-04     Completed Date:  2008-08-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806357     Medline TA:  J Clin Monit Comput     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  141-7     Citation Subset:  IM    
Division of Research, Singapore General Hospital, 31 Third Hospital Avenue, Bowyer Block A Level 3, Outram Road, Singapore 169608, Singapore,
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MeSH Terms
Blood Circulation Time / methods*
Blood Pressure Determination
Heart Rate / physiology
Linear Models
Myocardial Contraction / physiology
Upper Extremity / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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