Document Detail

Factors of severity at admission during an epidemic of dengue 1 in New Caledonia (South Pacific) in 2003.
MedLine Citation:
PMID:  16857614     Owner:  NLM     Status:  MEDLINE    
We report a retrospective study of an epidemic of dengue in New-Caledonia (South Pacific) in 2003 among adult inpatients. The aim was to establish clinical and biological criteria for the severity of the infection at the time of admission. During 7 months, all inpatients older than 15 y having a laboratory-confirmed diagnosis of dengue fever (IgM or PCR) were included (n=170). Two groups were defined: severe cases (death and/or transfer to intensive care unit, n=24) and benign cases (n=146). Data were analysed using Epi-Info software. Univariate analysis showed that shock, haemorrhage and neurological complications were significantly more frequent in serious cases, respectively 37.5% vs 0.7%, 62.5% vs 32.2%, 25% vs 9.6% (p<0.05). Relevant biological criteria were: creatinine > 140 micromol/l (OR 12 (95% CI 3.93-37.44)), free bilirubin > 18 micromol/l (OR 12.69 ( 95% CI 2.88-59.5)), amylase > 220 UI/l (OR 27.34 (95% CI 4.57-210)) and platelets < 45,000/mm3 (OR 4.35 (95% CI 1.43-14.2)) with p<0.005 (VPP = 100% for association of 3 criteria). We suggest this combination of 4 biological criteria inclines to severity.
M A Bouldouyre; F Baumann; A Berlioz-Arthaud; E Chungue; F Lacassin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of infectious diseases     Volume:  38     ISSN:  0036-5548     ISO Abbreviation:  Scand. J. Infect. Dis.     Publication Date:  2006  
Date Detail:
Created Date:  2006-07-21     Completed Date:  2006-10-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0215333     Medline TA:  Scand J Infect Dis     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  675-81     Citation Subset:  IM    
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MeSH Terms
Amylases / blood
Bilirubin / blood
Blood Platelets / cytology
Creatinine / blood
Dengue / blood,  diagnosis,  epidemiology*
Dengue Virus*
Immunoglobulin M / blood,  immunology
Intensive Care
Middle Aged
New Caledonia / epidemiology
Retrospective Studies
Reg. No./Substance:
0/Immunoglobulin M; 60-27-5/Creatinine; 635-65-4/Bilirubin; EC 3.2.1.-/Amylases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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