Document Detail


Factors related to treatment resistance in hypertension.
MedLine Citation:
PMID:  2274660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hypertension which is resistant to treatment carries a relatively bad prognosis. Factors associated with treatment resistance were examined in a case-control study in a hospital hypertension clinic. Patients with resistant hypertension had more severe hypertension and more frequently had evidence of end-organ damage on presentation to the clinic. The prevalence of accelerated phase hypertension, renovascular disease and impaired renal function was also higher in these patients. Cigarette smoking, and the combination of cigarette smoking and heavy caffeine use, were greater in patients with resistant hypertension. Resistant hypertension did not appear to be associated with older age, obesity, regular alcohol use, various psychological factors or non-compliance. These findings support an aggressive investigation policy in resistant hypertension, and underline the harmful effects of cigarette smoking to hypertensive subjects.
Authors:
J M Toner; C F Close; L E Ramsay
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Quarterly journal of medicine     Volume:  77     ISSN:  0033-5622     ISO Abbreviation:  Q. J. Med.     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-02-27     Completed Date:  1991-02-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401027     Medline TA:  Q J Med     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1195-204     Citation Subset:  IM    
Affiliation:
University Department of Pharmacology and Therapeutics, Royal Hallamshire Hospital, Sheffield.
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MeSH Terms
Descriptor/Qualifier:
Antihypertensive Agents / therapeutic use*
Anxiety / complications
Caffeine / adverse effects
Case-Control Studies
Drug Therapy, Combination
Female
Humans
Hypertension / complications,  drug therapy*
Kidney Diseases / complications
Male
Middle Aged
Prognosis
Smoking / adverse effects
Chemical
Reg. No./Substance:
0/Antihypertensive Agents; 58-08-2/Caffeine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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