Document Detail


Factors related to surgical complications and their impact on the functional status in 236 open surgeries for malignant tumors in a Latino-American hospital.
MedLine Citation:
PMID:  17905066     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There are not many studies that address the selection of patients harboring malignant brain tumors for open surgery. It is necessary, especially in developing countries, to establish the standards because of their impact not only on the efficacy but also on the cost-effectiveness of surgery. With the concern to add information that may help in future studies about the decision making, we proposed to analyze factors associated with surgical complications and evaluate their influence on the functional status at 30 days after surgery. METHODS: A consecutive series of 236 surgeries performed between June 1999 and June 2005 were retrospectively analyzed (168 gliomas, 65 metastases, 3 others). Variables evaluated were age, sex, pre- and postoperative KPS, ASA status, anatomic localization, extent of tumor resection, tumor histology, and number of surgeries. RESULTS: The incidence of complicated craniotomies was 15.68% and mortality was 2.97%. Postoperatively, 92% of the patients improved or maintained the functional status, whereas 8% worsened. In multivariate analysis, only preoperative KPS (P = .009), ASA status (P = .02), and histology type (P = .03) showed significant association with postoperative complications. CONCLUSIONS: We found that the neurologic and clinical preoperative condition and grade III gliomas were factors related to postoperative complications, whereas age, extent of resection, and number of surgeries were not risk factors. We believe that these conclusions provide an additional benchmark for future multicentric studies that focus on the selection criteria for resection of malignant brain tumors.
Authors:
Alejandra T Rabadán; Diego Hernandez; Martin Eleta; Marcelo Pietrani; Matteo Baccanelli; Silvia Christiansen; Carlos Teijido
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Surgical neurology     Volume:  68     ISSN:  0090-3019     ISO Abbreviation:  Surg Neurol     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-11-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0367070     Medline TA:  Surg Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  412-20; discussion 420     Citation Subset:  IM    
Affiliation:
Service of Neurosurgery, Hospital Italiano of Buenos Aires, 1181 Buenos Aires, Argentina. alejandrarabadan@speedy.com.ar
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Analysis of Variance
Anticonvulsants / therapeutic use
Brain Mapping
Brain Neoplasms / pathology,  physiopathology*,  surgery*
Craniotomy / adverse effects
Factor Analysis, Statistical
Female
Humans
Karnofsky Performance Status
Latin America / epidemiology
Length of Stay
Male
Middle Aged
Nervous System Diseases / epidemiology,  etiology
Neurosurgical Procedures / adverse effects*
Patient Selection
Platelet Aggregation Inhibitors / therapeutic use
Postoperative Complications / epidemiology*,  mortality
Reoperation
Sex Characteristics
Stockings, Compression
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Platelet Aggregation Inhibitors

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