Document Detail


Factors related to intracranial hematoma formation in patients receiving tissue-type plasminogen activator for acute ischemic stroke.
MedLine Citation:
PMID:  8303734     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND PURPOSE: Several studies are currently evaluating tissue-type plasminogen activator (TPA) as a potential therapy in acute ischemic stroke. The possibility of inducing intracranial hematomas, however, introduces an important concern into ultimate evaluation of risk and benefit. This retrospective analysis sought to identify factors associated with intracranial hematoma formation in a pilot phase 1 study of TPA for stroke. METHODS: Ninety-four patients received TPA within 3 hours of the onset of an acute ischemic stroke. Five of these patients developed a symptomatic intracerebral hematoma: 3 of 74 (4%) among patients treated within 90 minutes of stroke onset and 2 of 20 (10%) among those treated at 91 to 180 minutes. Three of the 5 died within 2 weeks. The analysis investigated associations between clinical factors and intracerebral hematomas. RESULTS: Factors significantly related to the development of an intracerebral hematoma were TPA dose and diastolic hypertension. Intracerebral hematomas developed in 4 (18%) of 22 patients given a TPA dose of at least 0.90 mg/kg versus only 1 hematoma in the remaining 72 patients (1%; P < .02, Fisher's exact test). Four (18%) of 22 patients who had initial diastolic blood pressures of at least 100 mm Hg suffered an intracerebral hematoma versus only 1 (1%) of 72 patients (P < .02) with lower initial diastolic pressures. CONCLUSIONS: Since the study was not designed to test specific safety hypotheses, results must not be overinterpreted. Nonetheless, these data emphasize the need for caution in both patient and dose selection for further studies of thrombolytic agents in stroke.
Authors:
D E Levy; T G Brott; E C Haley; J R Marler; G L Sheppard; W Barsan; J P Broderick
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  25     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-03-08     Completed Date:  1994-03-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  291-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, Cornell University Medical College, New York, NY.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Analysis of Variance
Aspirin / therapeutic use
Brain Ischemia / blood,  drug therapy*,  mortality
Cerebral Hemorrhage / etiology*
Female
Fibrinogen / analysis
Heparin / therapeutic use
Humans
Hypertension / complications
Male
Middle Aged
Pilot Projects
Recombinant Proteins / adverse effects,  therapeutic use
Retrospective Studies
Sex Factors
Thrombolytic Therapy / adverse effects*
Tissue Plasminogen Activator / adverse effects*,  therapeutic use
Grant Support
ID/Acronym/Agency:
NS-03342/NS/NINDS NIH HHS; NS-32324/NS/NINDS NIH HHS; NS-51007/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Recombinant Proteins; 50-78-2/Aspirin; 9001-32-5/Fibrinogen; 9005-49-6/Heparin; EC 3.4.21.68/Tissue Plasminogen Activator

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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