| Factors regulating tumor pressure in hepatocellular carcinoma and implications for tumor spread. | |
| | |
MedLine Citation:
|
PMID: 9252135 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
This study was performed to investigate factors determining tumor pressure (TP) in hepatocellular carcinoma (HCC) and a correlation of pressure gradient between TP and portal vein pressure (PVP) with tumor spread. TP and hepatic tissue pressure (HTP) were measured in 70 patients who underwent hepatic resection for HCC. Changes in TP after hepatic artery occlusion (HAO) or portal vein occlusion (PVO) were observed. HTP was elevated with worsening chronic liver disease, and exhibited a significant positive correlation with PVP. The TP was significantly higher in the encapsulated and the nonnecrotic HCCs. The pressure gradient (TP-PVP) was significantly greater in the encapsulated HCCs, especially in those with microscopic portal vein invasion (vp) or intrahepatic metastasis (im). HAO caused a greater decrease in TP than did PVO, with the decrease being particularly marked in the encapsulated HCCs. The TP of HCC was found to be regulated mainly by the presence or absence of a tumor capsule or necrosis, and partly by the hepatic arterial flow and PVP. Our study suggests that TP increases with capsule formation and that the pressure gradient between TP and PVP may be a causal factor in the dispersement of tumor cells into the portal vein. |
| | |
Authors:
|
T Tanaka; N Yamanaka; T Oriyama; K Furukawa; E Okamoto |
Related Documents
:
|
7384475 - Transfemoral balloon catheterization for hepatic wedge pressure measurements. 17927765 - Albumin infusion fails to restore circulatory function following paracentesis of tense ... 16029225 - Radial to femoral arterial blood pressure differences during liver transplantation. 21421595 - Effects of lowering dialysate sodium on flow-mediated dilatation in patients with chron... 23147135 - Engagement in occupational activities and pressure ulcer development in rehabilitated s... 17210855 - Identification of novel genetic loci for intraocular pressure: a genomewide scan of the... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Hepatology (Baltimore, Md.) Volume: 26 ISSN: 0270-9139 ISO Abbreviation: Hepatology Publication Date: 1997 Aug |
Date Detail:
|
Created Date: 1997-08-28 Completed Date: 1997-08-28 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8302946 Medline TA: Hepatology Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 283-7 Citation Subset: IM |
Affiliation:
|
First Department of Surgery, Hyogo College of Medicine, Mukogawa, Nishinomiya, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Carcinoma, Hepatocellular / pathology, physiopathology* Cell Differentiation Female Humans Liver Circulation Liver Neoplasms / pathology, physiopathology* Male Middle Aged Necrosis Pressure |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Cerebral benzodiazepine receptor binding in vivo in patients with recurrent hepatic encephalopathy.
Next Document: Hepatocytic phenotypes induced in sarcomatous cholangiocarcinoma cells treated with 5-azacytidine.