Document Detail

Factors potentiating the smoking-related risk of fetal growth retardation.
MedLine Citation:
PMID:  7999725     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the risk of fetal growth retardation resulting from the interaction between maternal smoking during pregnancy and other recognized risk factors. DESIGN: Case-control study of prospectively recorded data. SETTING: Department of Obstetrics and Gynaecology, University of Pavia, Italy. SUBJECTS: Three hundred and forty-seven singleton pregnancies with diagnosis of fetal growth retardation and 694 control pregnancies with appropriately grown fetuses. RESULTS: The overall odds ratio for fetal growth retardation associated with maternal smoking was 2.87 (95% confidence interval, 2.17-3.80). In logistic models the factors which independently increased the smoking-related risk of fetal growth retardation were a male fetus, nulliparity, maternal age 20 years or less, a history of first trimester haemorrhage and low (less than 50 kg) pre-pregnancy weight. The combined effect of smoking and caffeine consumption on the risk of fetal growth retardation was found to be additive rather than multiplicative. CONCLUSIONS: Several factors can affect the risk of fetal growth retardation associated with maternal smoking. The prenatal identification of these factors could help detect subgroups of women at high risk of fetal growth retardation.
A Spinillo; E Capuzzo; S E Nicola; L Colonna; T O Egbe; C Zara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  101     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-01-26     Completed Date:  1995-01-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  954-8     Citation Subset:  AIM; IM    
Department of Obstetrics and Gynaecology, University of Pavia, IRCCS San Matteo, Italy.
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MeSH Terms
Body Weight
Case-Control Studies
Fetal Growth Retardation / etiology*
Logistic Models
Maternal Age
Odds Ratio
Prospective Studies
Risk Factors
Sex Factors
Smoking / adverse effects*
Reg. No./Substance:

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