Document Detail


Factors modulating the outcome of treatment for the eradication of Helicobacter pylori infection.
MedLine Citation:
PMID:  22842603     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
A group of 180 H. pylori culture positive dyspeptic patients (64 patients with peptic ulcer, PU) completed a 2-week treatment with omeprazole, amoxicillin and metronidazole and underwent endoscopy again 6-8 weeks after the end of therapy. One hundred and twenty-four patients (68.8%) were successfully treated. Factors increasing the rates of eradication were the presence of PU (p=0.007) and anti-CagA serum antibodies (p=0.003). Factors negatively modulating eradication were the presence of coccoid forms (p=0.0008) and metronidazole-resistant strains (p=0.001); degrees of histological gastritis had no significant effect on eradication rates. Microscopic examination of smeared biopsies for the detection of the coccoid morphoytpe of H. pylori may help avoiding therapeutic failures.
Authors:
Natale Figura; Elena Moretti; L Vaglio; F Langone; Remo Vernillo; Carla Vindigni; Nicola Giordano
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Publication Detail:
Type:  Journal Article     Date:  2012-06-30
Journal Detail:
Title:  The new microbiologica     Volume:  35     ISSN:  1121-7138     ISO Abbreviation:  New Microbiol.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516291     Medline TA:  New Microbiol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  335-40     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine.
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