Document Detail


Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites.
MedLine Citation:
PMID:  16002454     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed simultaneous patch-electrode recordings from the soma and apical dendrite of CA1 pyramidal neurons in hippocampal slices, in order to determine the degree of voltage attenuation along CA1 dendrites. Fifty per cent attenuation of steady-state somatic voltage changes occurred at a distance of 238 microm from the soma in control and 409 microm after blocking the hyperpolarization-activated (H) conductance. The morphology of three neurons was reconstructed and used to generate computer models, which were adjusted to fit the somatic and dendritic voltage responses. These models identify several factors contributing to the voltage attenuation along CA1 dendrites, including high axial cytoplasmic resistivity, low membrane resistivity, and large H conductance. In most cells the resting membrane conductances, including the H conductances, were larger in the dendrites than the soma. Simulations suggest that synaptic potentials attenuate enormously as they propagate from the dendrite to the soma, with greater than 100-fold attenuation for synapses on many small, distal dendrites. A prediction of this powerful EPSP attenuation is that distal synaptic inputs are likely only to be effective in the presence of conductance scaling, dendritic excitability, or both.
Authors:
Nace L Golding; Timothy J Mickus; Yael Katz; William L Kath; Nelson Spruston
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2005-07-07
Journal Detail:
Title:  The Journal of physiology     Volume:  568     ISSN:  0022-3751     ISO Abbreviation:  J. Physiol. (Lond.)     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-10-11     Completed Date:  2005-11-28     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  0266262     Medline TA:  J Physiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  69-82     Citation Subset:  IM    
Affiliation:
Department of Neurobiology and Physiology, Institute for Neuroscience, Northwestern University, 2205 Tech Dr., Evanston, IL 60208-3520, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dendrites / physiology*
Excitatory Postsynaptic Potentials / physiology
Hippocampus / physiology*,  ultrastructure
Male
Models, Neurological
Neural Conduction / physiology
Patch-Clamp Techniques
Pyramidal Cells / physiology*,  ultrastructure
Rats
Rats, Wistar
Synaptic Transmission
Grant Support
ID/Acronym/Agency:
F32-NS-10532/NS/NINDS NIH HHS; R01-NS 46064/NS/NINDS NIH HHS; R01-NS35180/NS/NINDS NIH HHS; T32-GM-08061/GM/NIGMS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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