| Factors influencing white-coat effect. | |
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MedLine Citation:
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PMID: 18174883 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The transient blood pressure (BP) rise during clinical visits is usually referred to as white-coat effect (WCE). The aim of the present study was to investigate factors that may influence the WCE. METHODS: A total of 2004 subjects underwent office BP measurements and 24-h ambulatory BP monitoring (ABPM) on the same day. The WCE was estimated as the difference between office and average daytime ambulatory BP (ABP). According to the office and daytime BP values, the study population was divided into normotensives (NTs), white-coat hypertensives (WCHs), masked hypertensives (MHTs), and sustained hypertensives (SHTs). Statistical analyses were performed using one-way analysis of variance and multiple linear regression models. RESULTS: The mean systolic and diastolic WCE was 9 +/- 16 and 7 +/- 12 mm Hg, respectively. In the entire group of patients, multiple linear regression models revealed independent determinants of systolic WCE in the following rank order: office systolic BP (SBP) (beta = 0.727; P < 0.001), female gender (beta = 0.166; P < 0.001), daytime SBP variability (beta = 0.128; P < 0.001), age (beta = 0.039, P = 0.020), and smoking (beta = 0.031, P = 0.048). A 1.0 mm Hg increase in daytime SBP variability correlated with an increment of 0.589 mm Hg (95% confidence intervals, 0.437-0.741) in the systolic WCE. The regression analyses for diastolic WCE revealed the same factors as independent determinants. A 1.0 mm Hg increase in daytime diastolic BP (DBP) variability was independently associated with an increment of 0.418 mm Hg (95% confidence intervals, 0.121-0.715) in the diastolic WCE. CONCLUSIONS: Factors such as gender, age, smoking, office BPV and daytime BPV may exert an important influence on the magnitude of the WCE. |
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Authors:
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Efstathios D Manios; Eleni A Koroboki; Georgios K Tsivgoulis; Konstantinos M Spengos; Ioanna K Spiliopoulou; Fiona G Brodie; Konstantinos N Vemmos; Nikolaos A Zakopoulos |
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Publication Detail:
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Type: Journal Article Date: 2008-01-03 |
Journal Detail:
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Title: American journal of hypertension Volume: 21 ISSN: 0895-7061 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-02-12 Completed Date: 2008-04-24 Revised Date: 2009-02-24 |
Medline Journal Info:
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Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
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Languages: eng Pagination: 153-8 Citation Subset: IM |
Affiliation:
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Department of Clinical Therapeutics, Alexandra Hospital, University of Athens, Athens, Greece. stathismanios@yahoo.gr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Blood Pressure / physiology* Blood Pressure Monitoring, Ambulatory Circadian Rhythm / physiology* Female Humans Hypertension / epidemiology*, physiopathology* Linear Models Male Middle Aged Multivariate Analysis Physicians' Offices / statistics & numerical data* Prevalence Prognosis Risk Factors Sex Distribution Smoking / epidemiology |
| Comments/Corrections | |
Comment In:
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Am J Hypertens. 2008 Feb;21(2):135
[PMID:
18268486
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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