Document Detail


Factors influencing upfront single-and multiple-ovulation incidence, progesterone, and luteolysis before a timed insemination resynchronization protocol.
MedLine Citation:
PMID:  18024745     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objectives were to determine relationships among factors influencing responses to the first GnRH injection in a timed artificial insemination (TAI) protocol and subsequent fertility after altering timing of the second GnRH injection and AI relative to PGF(2alpha) injection. Replacement heifers (n = 86) and 613 lactating cows previously inseminated were diagnosed not pregnant to form 77 breeding clusters spanning 36 mo. At not-pregnant diagnosis (d 0), females received 100 mug of GnRH, and then 7 d later, they received 25 mg of PGF(2alpha). Females in 2 treatments received GnRH 48 h (G48) after PGF(2alpha) injection and TAI at the time of the second GnRH injection (G48 + TAI48) or 24 h later (G48 + TAI72). Females in the third treatment received GnRH 72 h after PGF(2alpha) when inseminated (G72 + TAI72). Neither timing of GnRH nor time of AI altered TAI pregnancy rates (average of 20.4%). Ovaries of females in 65 clusters were scanned on d 0 (first GnRH injection) and 7 d later (PGF(2alpha) injection). Ovarian structures were mapped and ovulation in response to the first GnRH injection was evaluated on d 7. When estrus was detected before scheduled TAI, females were inseminated; otherwise, TAI conception of remaining females was based on timing of GnRH and AI in 3 treatments. On d 7, 1 or more new corpora lutea (CL) were detected in 43% of females and their pregnancy rate was subsequently greater (28 vs. 18%) than those not ovulating. Follicle diameters on d 0 did not differ between females that did (11.9 +/- 0.3 mm) and did not (11.8 +/- 0.4 mm) subsequently ovulate in response to GnRH. Follicle diameter and number of follicles >/=5 mm increased with increasing lactation number, but decreased with increasing number of CL. Diameter of follicles in which more than 1 follicle ovulated decreased linearly from that in which only 1 follicle ovulated. Incidence of ovulation increased with increasing lactation number and total number of follicles >/=5 mm, but decreased with increasing number of CL. Incidence of multiple ovulations (15%) was greater in females having more follicles >/=5 mm and in those in early diestrus. Multiple ovulation did not occur in heifers, but was decreased in cows having more than 1 CL. In cows having more than 1 CL, luteal regression was reduced by 5.6 percentage units compared with those having 1 CL. In a TAI protocol, pregnancy rate was greater for females in early diestrus compared with females in other stages of the cycle, in those that ovulated after the first GnRH injection, in those having luteolysis, and in those inseminated during nonsummer months.
Authors:
J S Stevenson; M A Portaluppi; D E Tenhouse
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of dairy science     Volume:  90     ISSN:  1525-3198     ISO Abbreviation:  J. Dairy Sci.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-20     Completed Date:  2007-12-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985126R     Medline TA:  J Dairy Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  5542-51     Citation Subset:  IM    
Affiliation:
Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506-0201.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle / physiology*
Dinoprost / pharmacology*
Estrus Synchronization / methods
Female
Gonadotropin-Releasing Hormone / pharmacology*
Incidence
Insemination, Artificial / veterinary
Luteolysis / drug effects*,  physiology
Ovulation / drug effects*,  physiology
Ovulation Induction / methods,  veterinary
Pregnancy
Pregnancy Rate
Progesterone / blood*
Random Allocation
Time Factors
Chemical
Reg. No./Substance:
33515-09-2/Gonadotropin-Releasing Hormone; 551-11-1/Dinoprost; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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