|Factors influencing reticulophagocytic function in insulin-treated diabetes.|
|PMID: 6381177 Owner: NLM Status: MEDLINE|
|The splenic component of reticulophagocytic function (RPF) was examined in 29 insulin-treated diabetic subjects (13 type I and 16 type II) by measurement of clearance of altered, radiolabeled, autologous erythrocytes. Double-isotope studies were performed with cells altered by: (1) preincubation with N-ethylmaleimide (NEM) and (2) coating with IgG antibody to the Rhesus (Rh) D antigen, labeled with 99mTc and 51Cr, respectively. HLA typing for the A, B, and DR loci was performed in those patients showing a defect in the clearance of IgG-coated cells. Values for half-life (t1/2) were correlated with the incidence of diabetic complications, levels of HbA1, and circulating immune complexes (CIC). Two patterns of abnormal clearance were observed: first, an isolated defect of IgG-coated cell clearance in 7 patients (3 had the HLA B8/DR3 haplotype) and second, abnormal removal of both types of cell in a further 7 patients (3 had B8/DR3). There was no correlation between half-lives as measured by the two methods, although exclusion of the patients with a defect of IgG-coated cell clearance alone yielded a highly significant correlation for the remaining 15 Rh-positive patients (P less than 0.01). Abnormalities of IgG-coated cell clearance were more frequent in patients with HbA1 greater than 9% (P less than 0.02), while t1/2 of NEM-altered cells was significantly greater in patients with CIC (P less than 0.05). There was no correlation between t1/2 and the incidence of peripheral complications.(ABSTRACT TRUNCATED AT 250 WORDS)|
|S Lawrence; J A Charlesworth; B A Pussell; L V Campbell; M A Kotowicz|
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|Type: Journal Article; Research Support, Non-U.S. Gov't|
|Title: Diabetes Volume: 33 ISSN: 0012-1797 ISO Abbreviation: Diabetes Publication Date: 1984 Sep|
|Created Date: 1984-10-19 Completed Date: 1984-10-19 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 0372763 Medline TA: Diabetes Country: UNITED STATES|
|Languages: eng Pagination: 813-8 Citation Subset: AIM; IM|
|APA/MLA Format Download EndNote Download BibTex|
Antigen-Antibody Complex / analysis*
Chromium Radioisotopes / diagnostic use
Complement System Proteins / analysis*
Diabetes Mellitus / drug therapy, immunology*, physiopathology
Diabetes Mellitus, Type 1 / drug therapy, immunology
Diabetes Mellitus, Type 2 / drug therapy, immunology
Diabetic Nephropathies / immunology
Diabetic Retinopathy / immunology
HLA Antigens / analysis
Immunoglobulin G / analysis
Insulin / therapeutic use*
Macrophages / immunology*
Reticulocytes / immunology*
Spleen / blood supply
Technetium / diagnostic use
|0/Antigen-Antibody Complex; 0/Chromium Radioisotopes; 0/HLA Antigens; 0/Immunoglobulin G; 11061-68-0/Insulin; 7440-26-8/Technetium; 9007-36-7/Complement System Proteins|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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