Document Detail

Factors influencing oral cavity status during high-dose antineoplastic therapy: a secondary data analysis.
MedLine Citation:
PMID:  9802057     Owner:  NLM     Status:  MEDLINE    
PURPOSE/OBJECTIVES: To identify factors associated with oral cavity status in patients receiving high-dose antineoplastic therapy. DESIGN: Descriptive, correlational secondary analysis. SETTING: Midwestern university oncology special care unit. SAMPLE: 50 males and females, ages 15-69. METHODS: The Oral Assessment Guide (OAG) was used to assess oral cavity status every shift throughout hospitalization. Additional data were collected by chart audit. Correlations and Cox regression analysis were performed. MAIN RESEARCH VARIABLES: Oral cavity status, absolute granulocyte count, blood urea nitrogen (BUN), creatinine, mean OAG score during the preparative regimen (prep-OAG), age, and total body irradiation (TBI). FINDINGS: Elevated BUN and creatinine, higher prep-OAG, older age, and TBI were associated with higher OAG scores. Cox analysis revealed that TBI was predictive of an OAG score > or = 16, and an OAG score > or = 18 was predictive of death by day +20. CONCLUSIONS: Patients who receive TBI and chemotherapy in combination are most likely to experience severely compromised oral cavity status. Those who are older, have poorer oral status, and have decreased renal function are at increased risk. IMPLICATIONS FOR NURSING PRACTICE: High-risk patients must be identified early, and oral assessments and care must be given consistently to decrease morbidity and potential mortality.
A M Berger; J Eilers
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Oncology nursing forum     Volume:  25     ISSN:  0190-535X     ISO Abbreviation:  Oncol Nurs Forum     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-29     Completed Date:  1998-12-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7809033     Medline TA:  Oncol Nurs Forum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1623-6     Citation Subset:  IM; N    
College of Nursing, University of Nebraska Medical Center, Omaha, USA.
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MeSH Terms
Age Factors
Antineoplastic Agents / adverse effects*
Data Interpretation, Statistical
Middle Aged
Mouth Mucosa
Nursing Assessment
Oral Health*
Proportional Hazards Models
Retrospective Studies
Risk Factors
Stomatitis / chemically induced*,  nursing
Whole-Body Irradiation / adverse effects
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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