| Factors influencing the measurement of bioavailability, taking calcium as a model. | |
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MedLine Citation:
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PMID: 11285351 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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For non-metabolizable supplemental nutrients, bioavailability is effectively equivalent to absorbability. Methods for measuring absorbability (balance, pharmacokinetic, tracer, urine increment, evoked physiological responses, and in vitro) are briefly characterized and their utility compared. When intrinsic labeling of a source is possible, tracer methods are generally the most accurate and precise, as well as often the least expensive. Factors influencing the measured end points of the various methods are described briefly. These include source factors such as pharmaceutic formulation, subject factors such as mucosal mass and the need status of the absorbing subject, and co-ingested factors such as other foods or food constituents. Extensive experience has shown that absorbability is difficult to predict from knowledge of the chemistry of the source, or even from the results of in vitro testing. Hence direct measurement of absorbability is essential to assure regulators and the general public that the source delivers what it promises. |
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Authors:
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R P Heaney |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of nutrition Volume: 131 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2001 Apr |
Date Detail:
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Created Date: 2001-04-04 Completed Date: 2001-05-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1344S-8S Citation Subset: IM |
Affiliation:
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Creighton University, Osteoporosis Research Center, Omaha, NE 68131, USA. rheaney@creighton.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biological Availability* Blood / metabolism Calcium / pharmacokinetics Humans Methods Radioactive Tracers Urine / chemistry |
| Chemical | |
Reg. No./Substance:
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0/Radioactive Tracers; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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