| Factors influencing the level of circulating procoagulant microparticles in acute pulmonary embolism. | |
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MedLine Citation:
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PMID: 20800803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Flow cytometry has shown levels of platelet-derived microparticles (PMPs) and endothelial-derived microparticles (EMPs) to be elevated in deep-vein thrombosis. Cardiovascular risk factors can also contribute to hypercoagulability due to circulating procoagulant microparticles (CPMPs). AIMS: To investigate in a case-control study the respective contribution of pulmonary embolism and cardiovascular risk factors to the level of hypercoagulability due to CPMPs. METHODS: CPMP, PMP and EMP levels were measured in 45 consecutive patients (age 67.9 +/- 11.6 years; 66.7% men) admitted to an intensive care unit for acute pulmonary embolism (APE), 45 healthy control subjects with no history of venous thromboembolism or vascular risk factors (Controls(noCVRFs)), and 45 patients with cardiovascular risk factors (Controls(CVRFs)). APE was diagnosed by spiral computed tomography or scintigraphy. CPMP levels were assessed using a prothrombinase assay on platelet-depleted plasma (results expressed as nmol/L equivalent). RESULTS: CPMP levels were higher in APE patients than in Controls(noCVRFs) (medians 4.7 vs 3.2 nmol/L, interquartile ranges [IQRs] 2.9-11.1 vs 2.3-4.6 nmol/L; p=0.02). Similar results were reported for PMPs (medians 2.2 vs 1.9 nmol/L, IQRs 1.7-5.8 vs 1.4-2.4 nmol/L; p=0.02), whereas EMP levels were not significantly different. However, CPMP procoagulant activity was not significantly different in APE patients and Controls(CVRFs). CONCLUSIONS: CPMPs and PMPs were significantly elevated in APE patients vs Controls(noCVRFs), but this correlation was not significant when APE patients were compared with Controls(CVRFs). Our observations highlight the importance of adjusting for the presence of cardiovascular risk factors in conditions in which microparticle levels are raised. |
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Authors:
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Laurence Bal; Stéphane Ederhy; Emanuele Di Angelantonio; Florence Toti; Fatiha Zobairi; Ghislaine Dufaitre; Catherine Meuleman; Ziad Mallat; Franck Boccara; Alain Tedgui; Jean-Marie Freyssinet; Ariel Cohen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-13 |
Journal Detail:
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Title: Archives of cardiovascular diseases Volume: 103 ISSN: 1875-2128 ISO Abbreviation: Arch Cardiovasc Dis Publication Date: 2010 Jun-Jul |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-13 Revised Date: 2011-04-25 |
Medline Journal Info:
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Nlm Unique ID: 101465655 Medline TA: Arch Cardiovasc Dis Country: Netherlands |
Other Details:
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Languages: eng Pagination: 394-403 Citation Subset: IM |
Copyright Information:
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Copyright 2010. Published by Elsevier Masson SAS. |
Affiliation:
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Cardiology Department, Saint-Antoine University and Medical School, Assistance Publique-Hôpitaux de Paris, université Pierre-et-Marie-Curie, 75571 Paris cedex 12, France. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Aged Blood Coagulation* Blood Platelets / pathology* Cardiovascular Diseases / blood, etiology*, pathology Case-Control Studies Cell-Derived Microparticles / pathology* Chi-Square Distribution Endothelial Cells / pathology* Female Humans Linear Models Male Middle Aged Pulmonary Embolism / blood*, pathology*, radiography, radionuclide imaging Risk Assessment Risk Factors Thrombophilia / blood, etiology*, pathology Tomography, Spiral Computed |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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