| Factors influencing early results and complication rates of the thrombolytic treatment of lower limb ischemia with recombinant tissue-type plasminogen activator. | |
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MedLine Citation:
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PMID: 17069188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to determine the effect of comorbidity conditions on the early outcome and complication rates of thrombolytic treatment of lower limb ischaemia with recombinant tissue plasminogen activator (rt-PA). Clinical and procedural data of 82 patients treated for acute/subacute arterial/graft occlusion were analysed retrospectively. Early results and adverse events were recorded and evaluated statistically. Early resolution of ischemic symptoms was achieved in 67 (82%) patients with a median dose of 25.4 mg of rt-PA. Major bleeding was reported in 9 and minor bleeding in 6 cases (intracranial hemorrhage rate 1%, mortality rate 1%, major amputation rate 1%). Comorbidity conditions and patient characteristics did not statistically influence success and complication rates. Bleeding was observed in patients who received a higher dose of the thrombolytic agent (30.0 mg vs 24.3 mg). Comorbidity conditions have no effect on early outcome and adverse events after thrombolytic management of lower limb ischemia. Higher doses of rt-PA with prolonged infusion times increase the risk of occurrence of treatment-related bleeding. |
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Authors:
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Giuseppe Asciutto; Bruno Geier; Barbara Marpe; Thomas Hummel; Achim Mumme |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chirurgia italiana Volume: 58 ISSN: 0009-4773 ISO Abbreviation: Chir Ital Publication Date: 2006 Sep-Oct |
Date Detail:
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Created Date: 2006-10-30 Completed Date: 2006-12-20 Revised Date: 2009-11-11 |
Medline Journal Info:
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Nlm Unique ID: 0151753 Medline TA: Chir Ital Country: Italy |
Other Details:
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Languages: eng Pagination: 597-604 Citation Subset: IM |
Affiliation:
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Klinik für Gefälsschirugie, St Josef Hospital, Klinikum der Ruhr Universität, Bochum, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Female Fibrinolytic Agents / adverse effects, therapeutic use* Humans Ischemia / drug therapy* Lower Extremity / blood supply* Male Medical Records Middle Aged Retrospective Studies Risk Factors Thrombolytic Therapy / methods* Tissue Plasminogen Activator / adverse effects, therapeutic use* Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Fibrinolytic Agents; EC 3.4.21.68/Tissue Plasminogen Activator |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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