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Factors influencing the duration of late first and second-trimester termination of pregnancy with prostaglandin derivates.
MedLine Citation:
PMID:  21112135     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To examine the time interval between first induction and fetal expulsion in fetal defect-related termination of pregnancy and to determine the relevant factors that influence this time interval. STUDY DESIGN: Retrospective study involving singleton pregnancies that were terminated due to fetal abnormalities between 2005 and 2009. Induction was done by either 200μg misoprostol, 1mg gemeprost or in case of a previous caesarean section by 0.5mg dinoprostone gel or 1mg gemeprost. The length of the induction interval between first induction and fetal expulsion was examined according to different maternal and fetal characteristics. Univariate and multivariate logistic regression analyses were used to determine the significant contributors for a delivery within 24h. RESULTS: One hundred and eighty-four singleton pregnancies fulfilled the inclusion criteria. The median gestational age at first induction was 19.2 weeks of gestation. The median time interval between first induction and expulsion was 18h (25-75th centile, 11-30h) and in 59 (32.1%) cases, the induction interval was longer than 24h. Multivariate logistic regression analysis in the prediction of fetal expulsion within 24h after first induction indicated significant contribution from gestational age and history of spontaneous delivery without previous caesarean section. CONCLUSIONS: The only relevant contributors to an estimation of the time interval were gestational age and previous history of spontaneous delivery. By combining this information it was possible to correctly anticipate fetal expulsion within 24h after first induction in 90% of the cases.
Norbert Wagner; Harald Abele; Markus Hoopmann; Eva-Maria Grischke; Gunnar Blumenstock; Diethelm Wallwiener; Karl Oliver Kagan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-25
Journal Detail:
Title:  European journal of obstetrics, gynecology, and reproductive biology     Volume:  -     ISSN:  1872-7654     ISO Abbreviation:  Eur. J. Obstet. Gynecol. Reprod. Biol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375672     Medline TA:  Eur J Obstet Gynecol Reprod Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Obstetrics and Gynaecology, University of Tuebingen, Calwer Strasse 7, 72076 Tuebingen, Germany.
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