Document Detail


Factors influencing the difference between maternal and cord blood lead.
MedLine Citation:
PMID:  15778260     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To determine the factors that affect why some infants receive higher exposures relative to the mother's body burden than do others. METHODS: A total of 159 mother-infant pairs from a cohort of women receiving prenatal care at Magee-Womens Hospital in Pittsburgh, PA from 1992 to 1995 provided blood samples at delivery for lead determination. The difference between cord and maternal blood lead concentration (PbB) and a dichotomous variable indicator of higher cord than maternal PbB, were examined as indicators of relative transfer. Women were interviewed twice during the pregnancy about lifestyle, medical history, calcium nutrition, and physical activity. RESULTS: Higher blood pressure was associated with relatively greater cord compared with maternal PbB, as was maternal alcohol use. Sickle cell trait and higher haemoglobin were associated with a lower cord relative to maternal blood lead PbB. No association was seen with smoking, physical exertion, or calcium consumption. CONCLUSION: While reduction in maternal exposure will reduce fetal exposure, it may also be possible to mitigate infant lead exposure by reducing transfer from the pregnant woman. Interventions aimed at reducing blood pressure and alcohol consumption during pregnancy may be useful in this regard.
Authors:
E W Harville; I Hertz-Picciotto; M Schramm; M Watt-Morse; K Chantala; J Osterloh; P J Parsons; W Rogan
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Occupational and environmental medicine     Volume:  62     ISSN:  1470-7926     ISO Abbreviation:  Occup Environ Med     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-21     Completed Date:  2005-04-11     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9422759     Medline TA:  Occup Environ Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  263-9     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, University of North Carolina-Chapel Hill, CB #7435, Chapel Hill, NC 27599-7435, USA. ewh@unc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / adverse effects
Blood Pressure / physiology
Body Burden
Environmental Exposure / adverse effects
Female
Fetal Blood / chemistry*
Hemoglobins / analysis
Humans
Infant, Newborn
Lead / blood*,  toxicity
Longitudinal Studies
Maternal-Fetal Exchange / physiology
Mothers
Pregnancy
Sickle Cell Trait / blood
Grant Support
ID/Acronym/Agency:
R01-ES05738/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Hemoglobins; 7439-92-1/Lead
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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