| Factors influencing the concentration of cytokines during liver transplantation. | |
| | |
MedLine Citation:
|
PMID: 21094826 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Not only does the underlying disease that requires surgery constitute a significant stress to the human body, but also the surgery itself serves as a stressor. Cytokine secretion is activated in response to the surgical stress during liver transplantation. We examined 44 patients to compare cytokine levels, according to the underlying diseases causing liver failure (viral hepatitis vs alcoholic hepatitis), examining whether the values differed according to the model for end-stage liver disease (MELD) score [high (≥20) vs low (<20)]. Pro-inflammatory cytokines tumor necrosis factor (TNF)-α, interleukin (IL)1β, and IL-6 and anti-inflammatory cytokines IL-4 and IL-10 were quantified using sandwich enzyme- linked immunoassays at three times: (1) after inducing anesthesia, (2) 60 minutes after the start of the anhepatic period, and (3) 60 minutes after reperfusion. No difference in the level of any cytokine measured in our study was detected at any time point between the viral and the alcoholic hepatitis groups. Among the high MELD group, IL-1β and IL-4 contents were higher than in the low MELD group at all time points (P < .05). IL-10 concentrations at time 1 and TNF-α at time 2 were higher among the high MELD group (P < .05). In conclusion, the severity of the inflammatory and stress reactions expressed as cytokine concentrations did not differ according to the underlying liver disease, but did associate with the MELD score. |
| | |
Authors:
|
H-J Koh; K-H Ryu; M-L Cho; Y-J Heo; J Lee |
Related Documents
:
|
17910606 - Melatonin inhibits free radical-mediated mitochondrial-dependent hepatocyte apoptosis a... 22287606 - Emerging evidence for endoplasmic reticulum stress in the pathogenesis of idiopathic pu... 11474306 - Cytokines in the liver. 11481616 - Cc-chemokine receptor 6 and its ligand macrophage inflammatory protein 3alpha might be ... 21395376 - An insight into the early mechanisms of allergen-specific immunotherapy. 14555286 - Cytokine release by murine spleen cells following multiple low dose streptozotocin-indu... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Transplantation proceedings Volume: 42 ISSN: 1873-2623 ISO Abbreviation: Transplant. Proc. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0243532 Medline TA: Transplant Proc Country: United States |
Other Details:
|
Languages: eng Pagination: 3617-9 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Anesthesiology and Pain Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Intraoperative changes in hyponatremia as a risk factor for prolonged mechanical ventilation after l...
Next Document: Does model for end-stage liver disease score predict the short-term outcome of living donor liver tr...