| Factors influencing cell fatty acid composition and A40926 antibiotic complex production in Nonomuraea sp. ATCC 39727. | |
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MedLine Citation:
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PMID: 18651189 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A40926 is a glycopeptide antibiotic complex consisting of several structurally related factors. It is produced by fermentation of Nonomuraea sp. ATCC 39727 and the complex components differ in the structure of the fatty acid moiety linked to the aminoglucuronic acid unit. In previous work, we observed that the production of single factors in glycopeptide antibiotic complexes could be selectively enhanced by the addition of suitable precursors to the culture medium. In this contribution, we examine the effects of branched amino acid addition to fermentation of Nonomuraea sp. in a chemically defined minimal medium. The changes in the composition of cell fatty acids correlate to the fatty acid distribution within the A40926 complex in diverse cultivation conditions. Nonomuraea sp. prefers isobutyric, butyric and propionic acids as initiators of fatty acid biosynthesis. The relative amount of the produced fatty acids is significantly influenced by the availability of intermediates or final products from the amino acid catabolic pathways. Antibiotic complex composition closely reflects the cell fatty acid pattern, in agreement with the assumption that the antibiotic fatty acid moieties are synthesized by shortening the chain of cell fatty acids. |
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Authors:
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Srdjan Jovetic; Marina Feroggio; Flavia Marinelli; Giancarlo Lancini |
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Publication Detail:
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Type: Journal Article Date: 2008-07-24 |
Journal Detail:
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Title: Journal of industrial microbiology & biotechnology Volume: 35 ISSN: 1367-5435 ISO Abbreviation: J. Ind. Microbiol. Biotechnol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-09-11 Completed Date: 2009-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705544 Medline TA: J Ind Microbiol Biotechnol Country: England |
Other Details:
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Languages: eng Pagination: 1131-8 Citation Subset: IM |
Affiliation:
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Actygea S.r.l, via R. Lepetit 34, Gerenzano, VA, Italy. sjovetic@actygea.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Actinomycetales
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chemistry,
metabolism* Amino Acids / metabolism* Anti-Bacterial Agents / metabolism* Culture Media / chemistry, metabolism Fatty Acids / chemistry, metabolism* Fermentation Industrial Microbiology* Teicoplanin / analogs & derivatives*, chemistry, metabolism |
| Chemical | |
Reg. No./Substance:
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0/A 40926; 0/Amino Acids; 0/Anti-Bacterial Agents; 0/Culture Media; 0/Fatty Acids; 61036-62-2/Teicoplanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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