Document Detail


Factors influencing the assessment of lung function in mice with influenza-induced lung disease.
MedLine Citation:
PMID:  23134074     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Please cite this paper as: Larcombe et al. (2012) Factors influencing the assessment of lung function in mice with influenza-induced lung disease. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12034. Background  The constant-phase model (CPM) is commonly fit to respiratory system input impedance (Z(rs) ) to estimate lung mechanics. Driving signal frequencies and the method of model fitting may influence the results, especially in cases of severe lung disease or under severe bronchoconstriction. Objective  To illustrate the effects of different CPM fits to Z(rs) data using a mouse model of influenza-induced lung disease. Methods  BALB/c mice infected with influenza (or control) were challenged with methacholine. The CPM was fitted to Z(rs) , measured between 0·25 and 19·625 Hz, using both unweighted and weighted fits. The effect of different lowest frequencies was assessed. Results and Conclusions  For influenza-infected mice, the unweighted fit was poor, and airway resistance (R(aw) ) was often biologically impossible. The weighted fit provided more realistic estimates of R(aw) . Different model fits and minimal frequencies had little effect on tissue mechanics.
Authors:
Alexander N Larcombe; Graeme R Zosky; Cindy Thamrin; Elizabeth M Bozanich; Zoltán Hantos; Peter D Sly
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Influenza and other respiratory viruses     Volume:  -     ISSN:  1750-2659     ISO Abbreviation:  Influenza Other Respi Viruses     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101304007     Medline TA:  Influenza Other Respi Viruses     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Division of Clinical Sciences, Telethon Institute for Child Health Research & Centre for Child Health Research, University of Western Australia, Perth, WA, Australia. Airway Physiology/Imaging Research Group, Woolcock Institute of Medical Research, Sydney, NSW, Australia. Department of Medical Physics and Informatics, University of Szeged, Szeged, Hungary. Queensland Children's Medical Research Institute, University of Queensland, Brisbane, Qld, Australia.
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