Document Detail


Factors determining successful liver preservation for transplantation.
MedLine Citation:
PMID:  165789     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Auxiliary liver allotransplants will survive for relatively long periods of time after 24 hour hypothermic (10-12C), pulsatile perfusion. The best perfusate was a silica gel fraction of dog plasma with added potassium chloride gel made hyperosmolar with glucose. Further improvement could be achieved with added allopurinol and methylprednisolone. Nonpulsatile flow or lower temperatures were less effective preservation techniques.
Authors:
L H Toledo-Pereyra; R L Simmons; J S Najarian
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  181     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-08-07     Completed Date:  1975-08-07     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  289-98     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Allopurinol / pharmacology
Ammonia / blood
Animals
Aspartate Aminotransferases / blood
Bilirubin / blood
Cold Temperature
Cryoglobulins / pharmacology
Dogs
Female
Fractional Precipitation
Gels
Glucose / pharmacology
L-Lactate Dehydrogenase / blood
Liver / pathology
Liver Transplantation*
Male
Methylprednisolone / pharmacology
Organ Preservation / methods*
Osmolar Concentration
Perfusion / methods
Serum Albumin
Silicon Dioxide
Tissue Preservation / methods*
Transplantation, Homologous
Chemical
Reg. No./Substance:
0/Cryoglobulins; 0/Gels; 0/Serum Albumin; 315-30-0/Allopurinol; 50-99-7/Glucose; 635-65-4/Bilirubin; 7631-86-9/Silicon Dioxide; 7664-41-7/Ammonia; 83-43-2/Methylprednisolone; EC 1.1.1.27/L-Lactate Dehydrogenase; EC 2.6.1.1/Aspartate Aminotransferases
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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