| Factors determining normal adult height in girls with gonadotropin-dependent precocious puberty treated with depot gonadotropin-releasing hormone analogs. | |
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MedLine Citation:
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PMID: 18460564 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Several factors can affect adult height (AH) of patients with gonadotropin-dependent precocious puberty (GDPP) treated with depot GnRH analogs. OBJECTIVE: Our objective was to determine factors influencing AH in patients with GDPP treated with depot GnRH analogs. PATIENTS: A total of 54 patients (45 girls) with GDPP treated with depot GnRH analog who reached AH was included in the study. DESIGN: Univariate and multivariate analyses of the factors potentially associated with AH were performed in all girls with GDPP. In addition, clinical features of the girls who attained target height (TH) range were compared with those who did not. Predicted height using Bayley and Pinneau tables was compared with attained AH. RESULTS: In girls the mean AH was 155.3 +/- 6.9 cm (-1.2 +/- 1 sd) with TH range achieved by 81% of this group. Multiple regression analysis revealed that the interval between chronological age at onset of puberty and at the start of GnRH analog therapy, height sd scores (SDSs) at the start and end of therapy, and TH explained 74% of AH variance. The predicted height at interruption of GnRH therapy, obtained from Bayley and Pinneau tables for average bone age, was more accurate than for advanced bone age in both sexes. In boys the mean AH was 170.6 +/- 9.2 cm (-1 +/- 1.3 SDS), whereas TH was achieved by 89% of this group. CONCLUSIONS: The major factors determining normal AH in girls with GDPP treated with depot GnRH analogs were shorter interval between the onset of puberty and start of therapy, higher height SDS at the start and end of therapy, and TH. Therefore, prompt depot GnRH analog therapy in properly selected patients with GDPP is critical to obtain normal AH. |
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Authors:
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Vinicius Nahime Brito; Ana Claudia Latronico; Priscilla Cukier; Milena Gurgel Teles; Letícia F G Silveira; Ivo Jorge Prado Arnhold; Berenice Bilharinho Mendonca |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-05-06 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 93 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-11 Completed Date: 2008-08-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 2662-9 Citation Subset: AIM; IM |
Affiliation:
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Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, Disciplina de Endocrinologia e Metabologia, Avenida Dr. Eneas de Carvalho Aguiar, São Paulo, SP, Brazil. vinbrito@uol.com.br |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Body Height* Child Child, Preschool Female Gonadotropin-Releasing Hormone / therapeutic use* Gonadotropins / physiology* Goserelin / therapeutic use Humans Leuprolide / therapeutic use Luteinizing Hormone / blood Male Puberty, Precocious / drug therapy*, physiopathology Regression Analysis Triptorelin / therapeutic use |
| Chemical | |
Reg. No./Substance:
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0/Gonadotropins; 33515-09-2/Gonadotropin-Releasing Hormone; 53714-56-0/Leuprolide; 57773-63-4/Triptorelin; 65807-02-5/Goserelin; 9002-67-9/Luteinizing Hormone |
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