| Factors determining end-expiratory alveolar pressure after cardiac surgery. | |
| | |
MedLine Citation:
|
PMID: 10434169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Intrinsic positive end-expiratory pressure can occur when the sternum is closed following cardiac surgery, causing anaesthetic and surgical problems. We measured intrinsic positive end-expiratory pressure after sternal closure in two studies of patients undergoing coronary artery bypass grafting with the same anaesthetic regime. In one, patients were ventilated at 10 breaths min-1, in the other they were randomized to be ventilated at 10 or 20 breaths min-1. After sternal closure, intrinsic positive end-expiratory pressure increased significantly, especially in patients in whom it had been present before sternotomy. Multiple linear regressions with the pooled data from the studies showed that intrinsic positive end-expiratory pressure was positively correlated with ventilatory rate (P < 0.005), age (P < 0.005) and Body Mass Index (P < 0.0005), and negatively with FEV1, as percentage of predicted (P < 0.01). There was no correlation between intrinsic positive end-expiratory pressure and a history of smoking. As there was no difference in expiratory resistance between patients ventilated at the two different rates, any effect on intrinsic positive end-expiratory pressure of the higher ventilatory rates could have been due only to the shorter expiratory time. |
| | |
Authors:
|
R Fletcher; P Foster; S Thornton |
Related Documents
:
|
21587159 - Pressure controlled ventilation to induce acute lung injury in mice. 22051429 - "environmental hypertensionology" the effects of environmental factors on blood pressur... 19172089 - Bicycle saddle pressure: effects of trunk position and saddle design on healthy subjects. 23478229 - Hydrogen peroxide via thromboxane a2 receptors mediates myogenic response of small skel... 6150129 - Cardiovascular effects of a new positive inotropic agent, (-)-(r)-1-(p-hydroxyphenyl)-2... 17010639 - Development of leptin antagonists and their potential use in experimental biology and m... 6819599 - Treatment of status epilepticus with intravenous clonazepam. 9935049 - Cardiac sympathetic nervous system in early essential hypertension assessed by 123i-mibg. 16753319 - Non-invasive assessment of pulmonary hypertension: doppler-echocardiography. |
Publication Detail:
|
Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: European journal of anaesthesiology Volume: 16 ISSN: 0265-0215 ISO Abbreviation: Eur J Anaesthesiol Publication Date: 1999 Jun |
Date Detail:
|
Created Date: 1999-09-17 Completed Date: 1999-09-17 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8411711 Medline TA: Eur J Anaesthesiol Country: ENGLAND |
Other Details:
|
Languages: eng Pagination: 396-9 Citation Subset: IM |
Affiliation:
|
Central Manchester Hospitals NHS Trust, Manchester, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Age Factors Aged Airway Resistance Body Mass Index Coronary Artery Bypass* Female Forced Expiratory Volume Humans Linear Models Male Middle Aged Positive-Pressure Respiration, Intrinsic / etiology* Postoperative Complications* Respiration, Artificial / methods Risk Factors Sternum / surgery |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Comparison of ondansetron and tropisetron combined with droperidol for the prevention of emesis in w...
Next Document: Post-operative course after conventional or laparoscopic gastroplasty in morbidly obese patients.