| Factors controlling fat mobilization from human subcutaneous adipose tissue during exercise. | |
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MedLine Citation:
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PMID: 1938716 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate possible factors that limit fat utilization during exercise, arteriovenous differences of plasma nonesterified fatty acids (NEFA) and glycerol were measured across the subcutaneous adipose tissue of the anterior abdominal wall in nine subjects who exercised for 60 min at 50-70% of their maximal O2 consumption. The large gradient of NEFA concentration from adipose tissue venous to arterial plasma increased throughout the exercise period. Maximal plasma NEFA concentrations in adipose venous drainage were reached postexercise (median 3,800 mumol/l), with a median NEFA-to-albumin molar ratio of 5.7. Fractional reesterification of fatty acids within the tissue (assessed from the ratio of NEFA to glycerol release) was 20-30% in the basal state and declined during exercise. After exercise there was apparently negative reesterification, implying release of NEFA retained in adipose tissue during exercise. Although these findings challenge current views on the regulation of NEFA release, they are in agreement with the concept of supply of fatty acids from adipose tissue as the major factor limiting fat oxidation during sustained exercise. |
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Authors:
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V Hodgetts; S W Coppack; K N Frayn; T D Hockaday |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of applied physiology (Bethesda, Md. : 1985) Volume: 71 ISSN: 8750-7587 ISO Abbreviation: J. Appl. Physiol. Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-12-11 Completed Date: 1991-12-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8502536 Medline TA: J Appl Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 445-51 Citation Subset: IM |
Affiliation:
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Sheikh Rashid Diabetes Unit, Radcliffe Infirmary, Oxford, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism* Adult Blood Glucose / metabolism Electrocardiography Exercise / physiology* Fats / metabolism* Fatty Acids, Nonesterified / blood Female Glycerol / blood Humans Hydrocortisone / blood Insulin / blood Lactates / blood Male Norepinephrine / blood Oxygen / blood Oxygen Consumption Serum Albumin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Fats; 0/Fatty Acids, Nonesterified; 0/Lactates; 0/Serum Albumin; 11061-68-0/Insulin; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 56-81-5/Glycerol; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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