Document Detail

Factors controlling cardiac neural crest cell migration.
MedLine Citation:
PMID:  20890117     Owner:  NLM     Status:  MEDLINE    
Cardiac neural crest cells originate as part of the postotic caudal rhombencephalic neural crest stream. Ectomesenchymal cells in this stream migrate to the circumpharyngeal ridge and then into the caudal pharyngeal arches where they condense to form first a sheath and then the smooth muscle tunics of the persisting pharyngeal arch arteries. A subset of the cells continue migrating into the cardiac outflow tract where they will condense to form the aorticopulmonary septum. Cell signaling, extracellular matrix and cell-cell contacts are all critical for the initial migration, pauses, continued migration, and condensation of these cells. This review elucidates what is currently known about these factors.
Margaret L Kirby; Mary R Hutson
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell adhesion & migration     Volume:  4     ISSN:  1933-6926     ISO Abbreviation:  Cell Adh Migr     Publication Date:    2010 Oct-Dec
Date Detail:
Created Date:  2011-04-18     Completed Date:  2011-06-21     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101469464     Medline TA:  Cell Adh Migr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  609-21     Citation Subset:  IM    
Department of Pediatrics, Duke University, Durham, NC, USA.
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MeSH Terms
Cell Communication
Cell Movement / genetics
Epithelial-Mesenchymal Transition
Extracellular Matrix / metabolism
Ganglia, Autonomic / embryology
Heart / embryology*,  innervation
Intercellular Junctions / metabolism
Intracellular Signaling Peptides and Proteins / metabolism
Neural Crest / cytology*,  metabolism
Pharynx / blood supply,  embryology,  innervation
Grant Support
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins

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