Document Detail

Factors contributing to successful discontinuation from inhaled nitric oxide therapy in pediatric patients after congenital cardiac surgery.
MedLine Citation:
PMID:  15215004     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate variables that contribute to successful discontinuation from inhaled nitric oxide (iNO) therapy in children after surgical repair of congenital heart disease. DESIGN: Analysis of retrospectively collected data. SETTING: The pediatric intensive care unit of a university hospital. PATIENTS: A total of 65 pediatric patients receiving iNO therapy for the purpose of pulmonary circulation control after cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Patients were classified into two groups: those successfully weaned from iNO therapy on the initial attempt (group A, n = 45) and those for whom the initial attempt at weaning failed (group B, n = 20). Variables including intraoperative findings, postoperative hemodynamic and ventilatory variables, medication profiles, and dose and duration of iNO therapy were compared between groups. Using a multivariate logistic regression model, iNO therapy of >72 hrs (odds ratio, 5.6) and NO dose at discontinuation of <2 ppm (odds ratio, 4.1) were found to be significantly associated with successful weaning. Those results could be emphasized in a subgroup of left-to-right shunt cardiac anomaly. CONCLUSIONS: Longer continuation (>72 hrs) and lower final concentration (<2 ppm) represent factors contributing to successful discontinuation of iNO therapy in pediatric patients after cardiac surgery, specifically for children with left-to-right shunt correction.
Kyoko Kageyama; Nobuaki Shime; Munetaka Hirose; Noriko Hiramatsu; Hiromi Ashida; Satoru Hashimoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  5     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2004 Jul 
Date Detail:
Created Date:  2004-06-24     Completed Date:  2004-10-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  351-5     Citation Subset:  IM    
Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan.
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MeSH Terms
Administration, Inhalation
Heart Defects, Congenital / surgery*
Hypertension, Pulmonary / etiology,  prevention & control*
Intensive Care Units, Pediatric
Length of Stay / statistics & numerical data
Logistic Models
Nitric Oxide / administration & dosage*
Retrospective Studies
Time Factors
Reg. No./Substance:
10102-43-9/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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