| Factors contributing to successful discontinuation from inhaled nitric oxide therapy in pediatric patients after congenital cardiac surgery. | |
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MedLine Citation:
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PMID: 15215004 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To investigate variables that contribute to successful discontinuation from inhaled nitric oxide (iNO) therapy in children after surgical repair of congenital heart disease. DESIGN: Analysis of retrospectively collected data. SETTING: The pediatric intensive care unit of a university hospital. PATIENTS: A total of 65 pediatric patients receiving iNO therapy for the purpose of pulmonary circulation control after cardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Patients were classified into two groups: those successfully weaned from iNO therapy on the initial attempt (group A, n = 45) and those for whom the initial attempt at weaning failed (group B, n = 20). Variables including intraoperative findings, postoperative hemodynamic and ventilatory variables, medication profiles, and dose and duration of iNO therapy were compared between groups. Using a multivariate logistic regression model, iNO therapy of >72 hrs (odds ratio, 5.6) and NO dose at discontinuation of <2 ppm (odds ratio, 4.1) were found to be significantly associated with successful weaning. Those results could be emphasized in a subgroup of left-to-right shunt cardiac anomaly. CONCLUSIONS: Longer continuation (>72 hrs) and lower final concentration (<2 ppm) represent factors contributing to successful discontinuation of iNO therapy in pediatric patients after cardiac surgery, specifically for children with left-to-right shunt correction. |
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Authors:
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Kyoko Kageyama; Nobuaki Shime; Munetaka Hirose; Noriko Hiramatsu; Hiromi Ashida; Satoru Hashimoto |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies Volume: 5 ISSN: 1529-7535 ISO Abbreviation: Pediatr Crit Care Med Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-24 Completed Date: 2004-10-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100954653 Medline TA: Pediatr Crit Care Med Country: United States |
Other Details:
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Languages: eng Pagination: 351-5 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Kyoto Prefectural University of Medicine, Kyoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Female Heart Defects, Congenital / surgery* Hemodynamics Humans Hypertension, Pulmonary / etiology, prevention & control* Infant Intensive Care Units, Pediatric Length of Stay / statistics & numerical data Logistic Models Male Nitric Oxide / administration & dosage* Retrospective Studies Time Factors |
| Chemical | |
Reg. No./Substance:
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10102-43-9/Nitric Oxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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