| Factors contributing to plasma TCO(2) and acid-base state in Ontario Standardbred racehorses. | |
| | |
MedLine Citation:
|
PMID: 21059066 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Reasons for performing study: Standardbred and Thoroughbred racehorses around the world are tested for performance enhancing substances. Among these are blood alkalising substances that raise plasma pH and total carbon dioxide (TCO(2) ) concentration. However, many horses have an elevated TCO(2) due to dietary, environmental and health concerns without having been administered an alkalising substance. Objectives: The purposes of this study were to determine the acid-base profile of a cross section of Standardbred horses in racing/race training in Ontario and the main independent variables that contributed to acid-base state. Materials and methods: On nonracing days, blood from 211 horses at rest, from 9 training facilities, was analysed within 30 min for plasma pH (7.406 ± 0.039; mean ± s.e.), PCO(2) (50.0 ± 3.4 mmHg), from which [HCO(3) (-) ] (31.2 ± 2.8 mmol/l) and [TCO(2) ] (33.1 ± 2.9 mmol/l; range 25.66-42.9) were calculated. From these, a subset of 161 horses had full data sets for plasma protein and strong ion concentrations. These data were further analysed by facility and level of TCO(2) . Data on nutrition, training, racing and medications were also collected. Results: There were significant differences amongst facilities with respect to plasma pH, TCO(2) , strong ion difference ([SID]), PCO(2) and total weak acid concentration ([A(tot) ]). Horses having the highest TCO(2) (37.0-42.9 mmol/l, n = 16) had significantly higher [SID] (52.9 ± 0.8 mEq/l) and PCO(2) (52.5 ± 0.7 mmHg) and relatively low [A(tot) ] (14.9 ± 0.7 mEq/l) compared to average TCO(2) (32.1.0-34.9 mmol/l) horses (n = 75). In horses with the lowest TCO(2) (n = 11) the greatest contributor was elevated [A(tot) ] (21.0 ± 0.7 mEq/l) and unmeasured (acetate, citrate, proprionate, butyrate) weak acids (7.0 ± 0.2 mEq/l) while [SID] (49.6 ± 0.8 mEq/l) and PCO(2) (47.8 ± 1.0 mmHg) were similar to average TCO(2) horses. Thirty-two horses had a TCO(2) ranging from 35.0-36.9 mmol/l). Conclusions: There is a wide range of acid-base state and factors contributing to acid-base state amongst Standardbred race horses in Ontario. Dietary, environmental and handling practices and health concerns, that elevate plasma [SID], lower [A(tot) ] and lower the concentration of unmeasured weak acids are the primary contributors to alkalosis and elevated TCO(2) . |
| | |
Authors:
|
A P Waller; W Pearson; M I Lindinger |
Related Documents
:
|
22202876 - Production of volatile compounds by lactobacillus sakei from branched chain α-keto acids. 7820306 - Influence of fatty acids and bovine serum albumin on the growth of human hepatoma and i... 16658396 - Control of the formation of amylases and proteases in the cotyledons of germinating peas. 8403846 - Prostaglandin-like activity, fatty acid and phospholipid composition of sika deer (cerv... 20594096 - Impact of a stage-tailored, web-based intervention on folic acid-containing multivitami... 1688706 - Effect of an oral tryptophan/carbohydrate load on tryptophan, large neutral amino acid,... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Equine veterinary journal Volume: 42 Suppl 38 ISSN: 2042-3306 ISO Abbreviation: Equine Vet. J. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0173320 Medline TA: Equine Vet J Country: England |
Other Details:
|
Languages: eng Pagination: 592-600 Citation Subset: IM |
Copyright Information:
|
© 2010 EVJ Ltd. |
Affiliation:
|
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Assessment of the exercise tests used during overground endoscopy in UK Thoroughbred racehorses and ...
Next Document: Efficacy of single-dose intravenous phenylbutazone and flunixin meglumine before, during and after e...