| Factors contributing to peritoneal tissue remodeling in peritoneal dialysis. | |
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MedLine Citation:
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PMID: 19910560 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peritoneal dialysis (PD) is associated with functional and structural changes of the peritoneal membrane. In this review we describe factors contributing to peritoneal tissue remodeling, including uremia, peritonitis, volume loading, the presence of a catheter, and the PD fluid itself. These factors initiate recruitment and activation of peritoneal cells such as macrophages and mast cells, as well as activation of peritoneal cells, including mesothelial cells, fibroblasts, and endothelial cells. We provide an overview of cytokines, growth factors, and other mediators involved in PD-associated changes. Activation of downstream pathways of cellular modulators can induce peritoneal tissue remodeling, leading to ultrafiltration loss. Identification of molecular pathways, cells, and cytokines involved in the development of angiogenesis, fibrosis, and membrane failure may lead to innovative therapeutic strategies that can protect the peritoneal membrane from the consequences of long-term PD. |
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Authors:
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Margot N Schilte; Johanna W A M Celie; Piet M ter Wee; Robert H J Beelen; Jacob van den Born |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis Volume: 29 ISSN: 0896-8608 ISO Abbreviation: Perit Dial Int Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-11-13 Completed Date: 2011-01-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8904033 Medline TA: Perit Dial Int Country: Canada |
Other Details:
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Languages: eng Pagination: 605-17 Citation Subset: IM |
Affiliation:
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Department of Molecular Cell Biology, VU University Medical Center, Amsterdam, The Netherlands. m.schilte@vumc.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cytokines
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physiology Hormones / physiology Humans Intercellular Signaling Peptides and Proteins / physiology Peritoneal Dialysis* / adverse effects Peritoneum / pathology* Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Cytokines; 0/Hormones; 0/Intercellular Signaling Peptides and Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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