Document Detail

Factors contributing to adverse soft tissue reactions due to the use of tartar control toothpastes: report of a case and literature review.
MedLine Citation:
PMID:  10440643     Owner:  NLM     Status:  MEDLINE    
Tetrasodium and/or tetrapotassium pyrophosphate (Ppi) is the anticalculus component of most tartar control dentifrices on the market today. While pyrophosphates alone are not responsible for hypersensitivity reactions, several modifications which may lead to adverse oral manifestations may occur when pyrophosphates are added to a dentifrice. First, tetrasodium pyrophosphate in a dentifrice forms a slightly alkaline solution upon oral use which could irritate oral membranes. Second, increased concentrations of flavoring agents, known to be sensitizers, are needed to mask the strong bitter taste of pyrophosphates. Third, increased concentrations of detergents, capable of producing hypersensitivity reactions, are necessary to allow the pyrophosphates to become soluble in the dentifrice. Fourth, a pre-existing condition of reduced salivary flow may augment hypersensitivity to tartar control toothpastes. While pyrophosphates have been approved as additives in dentifrices, these compounds along with the increased concentrations of flavorings and detergents and their higher intraoral alkalinity are strongly implicated as the causative factor in certain hypersensitivity reactions.
V F DeLattre
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Journal of periodontology     Volume:  70     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-10     Completed Date:  1999-09-10     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  803-7     Citation Subset:  D; IM    
The University of Texas - Houston Health Science Center Dental Branch 77030, USA.
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MeSH Terms
Alkalies / adverse effects
Dental Calculus / prevention & control*
Detergents / adverse effects
Diphosphates / adverse effects*
Flavoring Agents / adverse effects
Hypersensitivity / etiology
Irritants / adverse effects
Mouth Mucosa / drug effects*
Potassium Compounds / adverse effects
Stomatitis / chemically induced*
Toothpaste / adverse effects*
Xerostomia / complications
Reg. No./Substance:
0/Alkalies; 0/Detergents; 0/Diphosphates; 0/Flavoring Agents; 0/Irritants; 0/Potassium Compounds; 0/Toothpaste; 7320-34-5/tetrapotassium pyrophosphate; 7722-88-5/sodium pyrophosphate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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