| Factors contributing to adverse soft tissue reactions due to the use of tartar control toothpastes: report of a case and literature review. | |
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MedLine Citation:
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PMID: 10440643 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tetrasodium and/or tetrapotassium pyrophosphate (Ppi) is the anticalculus component of most tartar control dentifrices on the market today. While pyrophosphates alone are not responsible for hypersensitivity reactions, several modifications which may lead to adverse oral manifestations may occur when pyrophosphates are added to a dentifrice. First, tetrasodium pyrophosphate in a dentifrice forms a slightly alkaline solution upon oral use which could irritate oral membranes. Second, increased concentrations of flavoring agents, known to be sensitizers, are needed to mask the strong bitter taste of pyrophosphates. Third, increased concentrations of detergents, capable of producing hypersensitivity reactions, are necessary to allow the pyrophosphates to become soluble in the dentifrice. Fourth, a pre-existing condition of reduced salivary flow may augment hypersensitivity to tartar control toothpastes. While pyrophosphates have been approved as additives in dentifrices, these compounds along with the increased concentrations of flavorings and detergents and their higher intraoral alkalinity are strongly implicated as the causative factor in certain hypersensitivity reactions. |
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Authors:
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V F DeLattre |
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Publication Detail:
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Type: Case Reports; Journal Article; Review |
Journal Detail:
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Title: Journal of periodontology Volume: 70 ISSN: 0022-3492 ISO Abbreviation: J. Periodontol. Publication Date: 1999 Jul |
Date Detail:
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Created Date: 1999-09-10 Completed Date: 1999-09-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 803-7 Citation Subset: D; IM |
Affiliation:
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The University of Texas - Houston Health Science Center Dental Branch 77030, USA. vdelattr@mail.db.uth.tmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Alkalies / adverse effects Dental Calculus / prevention & control* Detergents / adverse effects Diphosphates / adverse effects* Female Flavoring Agents / adverse effects Humans Hypersensitivity / etiology Irritants / adverse effects Mouth Mucosa / drug effects* Potassium Compounds / adverse effects Stomatitis / chemically induced* Toothpaste / adverse effects* Xerostomia / complications |
| Chemical | |
Reg. No./Substance:
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0/Alkalies; 0/Detergents; 0/Diphosphates; 0/Flavoring Agents; 0/Irritants; 0/Potassium Compounds; 0/Toothpaste; 7320-34-5/tetrapotassium pyrophosphate; 7722-88-5/sodium pyrophosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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