Document Detail

Factors of carotid arterial enlargement in a population aged 59 to 71 years: the EVA study.
MedLine Citation:
PMID:  8614925     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Factors of carotid arterial enlargement are not well known in general populations. The purpose of this study was to assess the cross-sectional associations of arterial wall lesions and cardiovascular risk factors with carotid lumen diameter in elderly subjects. METHODS: B-mode ultrasound examinations of the carotid arteries and risk factor assessment were made in 1272 participants in the EVA (Etude sur le vieillissement artériel) Study, a longitudinal study designed to evaluate vascular and cognitive aging in men and women aged 59 to 71 years. Ultrasound examinations included measurements of intima-media thickness (IMT) and interadventitial and lumen diameters of the common carotid arteries and quantification of atherosclerotic plaques in extracranial carotid arteries. RESULTS: Men showed greater IMT interadventitial and lumen diameters of the common carotid arteries than did women. In both sexes, common IMT and plaque score were positively associated with common interadventitial and lumen diameters. Stepwise multiple regression analysis showed that male sex, body height and weight, common IMT, plaque score, systolic blood pressure, and alcohol consumption were positively and independently related to lumen diameter. On the other hand, an independent negative association was observed between low density lipoprotein cholesterol and lumen diameter. CONCLUSIONS: In 59- to 71-year-old subjects, increased IMT and atherosclerotic plaques were accompanied by an increase in lumen diameter of the common carotid arteries, indicating an overcompensation. Luminal enlargement observed with several risk factors and with high blood pressure in particular might be partially counteracted by high lipid levels.
C Bonithon-Kopp; P J Touboul; C Berr; C Magne; P Ducimetière
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Stroke; a journal of cerebral circulation     Volume:  27     ISSN:  0039-2499     ISO Abbreviation:  Stroke     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-06-05     Completed Date:  1996-06-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0235266     Medline TA:  Stroke     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  654-60     Citation Subset:  IM    
INSERM U 248, Hopital Broussais, Paris, France.
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MeSH Terms
Aging / physiology*
Alcohol Drinking
Analysis of Variance
Arteriosclerosis / diagnosis,  epidemiology*
Blood Glucose / analysis
Blood Pressure
Carotid Arteries / anatomy & histology,  pathology,  ultrasonography*
Carotid Artery Diseases / diagnosis,  epidemiology*
Carotid Artery, Common / pathology,  ultrasonography
Cholesterol / blood
Cholesterol, HDL / blood
Cholesterol, LDL / blood
Coronary Disease / epidemiology,  ultrasonography
Diabetes Mellitus / epidemiology,  ultrasonography
Hypertension / epidemiology,  ultrasonography
Longitudinal Studies
Middle Aged
Regression Analysis
Risk Factors
Sex Characteristics
Sex Factors
Triglycerides / blood
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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