Document Detail

Factors associated with small head circumference at birth among infants born before the 28th week.
MedLine Citation:
PMID:  20541727     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We sought to identify risk factors for congenital microcephaly in extremely low gestational age newborns.
STUDY DESIGN: Demographic, clinical, and placental characteristics of 1445 infants born before the 28th week were gathered and evaluated for their relationship with congenital microcephaly.
RESULTS: Almost 10% of newborns (n = 138), rather than the expected 2.2%, had microcephaly defined as a head circumference >2 SD below the median. In multivariable models, microcephaly was associated with nonwhite race, severe intrauterine growth restriction, delivery for preeclampsia, placental infarction, and being female. The risk factors for a head circumference between <1 and >2 SD below the median were similar to those of microcephaly.
CONCLUSION: Characteristics associated with fetal growth restriction and preeclampsia are among the strongest correlates of microcephaly among children born at extremely low gestational ages. The elevated risk of a small head among nonwhites and females might reflect the lack of appropriate head circumference standards.
Thomas F McElrath; Elizabeth N Allred; Karl Kuban; Jonathan L Hecht; Andrew Onderdonk; T Michael O'Shea; Nigel Paneth; Alan Leviton;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2010-06-12
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  203     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-27     Completed Date:  2010-08-17     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  138.e1-8     Citation Subset:  AIM; IM    
Copyright Information:
Published by Mosby, Inc.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Brigham and Women's Hospital, Boston, MA, USA.
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MeSH Terms
Child Development / physiology
Delivery, Obstetric / methods
Fetal Growth Retardation / diagnosis*,  epidemiology
Follow-Up Studies
Gestational Age
Head / growth & development
Infant Mortality / trends
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature*
Microcephaly / diagnosis*,  epidemiology*
Pregnancy Trimester, Second*
Risk Assessment
Grant Support
K12 HDO1255//PHS HHS; U01 NS 400069-01/NS/NINDS NIH HHS; U01 NS040069-01A2/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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