Document Detail


Factors associated with serum thyroglobulin levels in a population living in Belarus.
MedLine Citation:
PMID:  23190420     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population. However, few studies have addressed the epidemiology of Tg in a population-based setting or in the context of exposure to radioactive iodine-131 (I-131). Our objective was to evaluate baseline levels of Tg in relation to sociodemographic characteristics, iodine status and thyroid function for individuals exposed to I-131.
DESIGN: A population-based cohort assembled in Belarus following the Chornobyl accident provided demographic factors, clinical data and physiological measurements.
PARTICIPANTS: Our analytical sample included 10,344 subjects of whom 7890 had no thyroid disease and 2454 had evidence of structural or functional thyroid abnormality.
MEASUREMENTS: Standardized assays were used to measure serum Tg, urinary iodine, TSH and antibodies to Tg and thyroid peroxidase. Ultrasound was used to assess the presence of nodules and estimate thyroid volume.
RESULTS: In the fully adjusted model, percent change in Tg was significantly increased among females, smokers and subjects of older age and Tg increased with decreasing urinary iodine concentration, increasing serum TSH and increasing thyroid volume (P-values for trend <0·0001), and presence of thyroid nodules (P < 0·05). We found a complex interaction between region of residence, rural/urban living, presence/absence of thyroid abnormalities and serum Tg (P < 0·0001).
CONCLUSIONS: In residents of Belarus, serum Tg is significantly related to presence of thyroid abnormalities as well as indicators of thyroid function and iodine deficiency and, therefore, could be used to characterize the iodine status and thyroid function of individuals in the context of epidemiological study.
Authors:
Elizabeth K Cahoon; Alexander Rozhko; Maureen Hatch; Olga Polyanskaya; Evgenia Ostroumova; Min Tang; Eldar Nadirov; Vasilina Yauseyenka; Irina Savasteeva; Robert J McConnell; Ruth M Pfeiffer; Alina V Brenner
Publication Detail:
Type:  Journal Article     Date:  2013-04-27
Journal Detail:
Title:  Clinical endocrinology     Volume:  79     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-06-04     Completed Date:  2014-01-06     Revised Date:  2014-07-02    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  120-7     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons Ltd.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antibodies / blood,  immunology
Chernobyl Nuclear Accident
Child
Cohort Studies
Female
Humans
Iodide Peroxidase / immunology
Iodine Radioisotopes / urine
Male
Multivariate Analysis
Republic of Belarus / epidemiology
Rural Population / statistics & numerical data
Socioeconomic Factors
Thyroglobulin / biosynthesis*,  immunology
Thyroid Diseases / blood*,  epidemiology,  urine
Thyroid Function Tests
Thyroid Gland / metabolism,  pathology*
Thyrotropin / blood,  metabolism
Urban Population / statistics & numerical data
Young Adult
Grant Support
ID/Acronym/Agency:
ZIA CP010132-17/CP/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies; 0/Iodine Radioisotopes; 9002-71-5/Thyrotropin; 9010-34-8/Thyroglobulin; EC 1.11.1.8/Iodide Peroxidase
Comments/Corrections

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