Document Detail


Factors associated with the seroprevalence of 26 cutaneous and two genital human papillomavirus types in organ transplant patients.
MedLine Citation:
PMID:  21900419     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Viral skin infections are commonly present in organ transplant recipients (OTR). In this study, we aimed to identify factors associated with human papillomavirus (HPV) infections in OTR. Patients with solid-organ transplants were recruited from the outpatient nephrology and dermatology clinics in five European countries. Only patients with no current or past skin cancer were included in this analysis. Serum samples were analysed for antibodies to the L1 proteins of 26 cutaneous and two genital HPV types from five phylogenetic genera (α, β, γ, μ and ν). The most consistent association was found between recreational sun exposure and the seroprevalence of all tested genera, except α. The antibody presence of any β type was higher among people who had been transplanted at least 23 years prior to participation than in those who had been transplanted for less than 7 years. The prevalence of two γ-HPV types (60 and 65) and three β-HPV types (15, 38 and 49) was associated with time since transplantation. The presence of a high number of warts was associated with the presence of any μ-PV or ν-PV types, and having greater than 50 keratotic skin lesions was almost significantly associated with the presence of antibodies to two or more γ-PV. Discrepancies in the results of the present study, as well as in previous reports, may depend on different methodologies and on geographical variations. Our results also indicate that further research with more standardized methods is needed to clarify the role of cutaneous HPV in OTR.
Authors:
F Sampogna; J N Bouwes Bavinck; M Pawlita; D Abeni; C A Harwood; C M Proby; M C W Feltkamp; S Euvrard; L Naldi; R E Neale; I Nindl; H Pfister; W G V Quint; T Waterboer;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-07
Journal Detail:
Title:  The Journal of general virology     Volume:  93     ISSN:  1465-2099     ISO Abbreviation:  J. Gen. Virol.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-20     Completed Date:  2012-02-14     Revised Date:  2014-07-22    
Medline Journal Info:
Nlm Unique ID:  0077340     Medline TA:  J Gen Virol     Country:  England    
Other Details:
Languages:  eng     Pagination:  165-74     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Antibodies, Viral / immunology*
Europe / epidemiology
Female
Genital Diseases, Female / epidemiology,  immunology*,  virology
Genital Diseases, Male / epidemiology,  immunology*,  virology
Humans
Male
Middle Aged
Papillomaviridae / classification,  genetics,  immunology*
Papillomavirus Infections / epidemiology,  immunology*,  virology
Phylogeny
Seroepidemiologic Studies
Skin Diseases, Viral / epidemiology,  immunology*,  virology
Transplants / adverse effects,  virology*
Grant Support
ID/Acronym/Agency:
13044//Cancer Research UK; G0700814//Medical Research Council
Chemical
Reg. No./Substance:
0/Antibodies, Viral
Investigator
Investigator/Affiliation:
J N Bouwes Bavinck / ; P van der Zwan-Kralt / ; Y G L de Graaf / ; L E Vos / ; E J Uphoff-Meijerink / ; R Willemze / ; M C W Feltkamp / ; L Struijk / ; P Wanningen / ; P Z van der Meijden / ; E I Plasmeijer / ; R Wolterbeek / ; S Euvrard / ; A C Butnaru / ; A Claudy / ; J Kanitakis / ; I Nindl / ; E Stockfleth / ; T Forschner / ; L Naldi / ; A Pizzagalli / ; F Sassi / ; G Tessari / ; C A Harwood / ; C M Proby / ; J Breuer / ; L Mitchell / ; K Purdie / ; S R Lambert / ; H Ran / ; H Pfister / ; U Wieland / ; S Weissenborn / ; M Pawlita / ; T Waterboer / ; P Sehr / ; K M Michael / ; W G V Quint / ; M N C de Koning / ; J ter Schegget / ; B Kleter / ; L J van Doorn / ; D Abeni / ; F Sampogna / ; T J Mannooranparampil / ; N Melo-Salcedo / ; S Simoni / ; G P Petasecca Donati / ; C Masini / ; C Deppermann Fortes / ; A C Green / ; R Neale / ; C Olsen / ; P O'Rourke / ; K-A Mallitt / ; S Harrison / ; P Buttner /

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