Document Detail


Factors associated with recurrence of cervical intraepithelial neoplasia 2+ after treatment among HIV-infected women in Western Kenya.
MedLine Citation:
PMID:  24662299     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HIV-infected women are at increased risk for recurrence of cervical dysplasia after treatment. Short-term recurrence rates may reflect treatment efficacy and therefore impact screening protocols and follow-up planning. We conducted a prospective study of 297 HIV-infected women undergoing loop electrosurgical excision procedure for cervical intraepithelial neoplasia 2+ (CIN2+) in an HIV clinic in Kisumu, Kenya. By 6 months after the procedure, 20 (7.1%) of women had recurrent CIN2+. Recurrence was significantly associated with CD4 nadir but not with highly active antiretroviral therapy use. Longer-term follow-up of this cohort will illustrate the potential impact of highly active antiretroviral therapy and immune status on CIN2/3 disease recurrence.
Authors:
Megan J Huchko; Hannah Leslie; May Maloba; Elizabeth A Bukusi; Craig R Cohen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  66     ISSN:  1944-7884     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2014 Jun 
Date Detail:
Created Date:  2014-05-14     Completed Date:  2014-07-03     Revised Date:  2014-09-19    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  188-92     Citation Subset:  IM; X    
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MeSH Terms
Descriptor/Qualifier:
Adult
Antiretroviral Therapy, Highly Active
CD4 Lymphocyte Count
Female
Follow-Up Studies
HIV Infections / complications,  epidemiology*
Humans
Kenya / epidemiology
Neoplasm Recurrence, Local / complications,  epidemiology*
Prospective Studies
Risk Factors
Uterine Cervical Dysplasia / complications,  epidemiology*,  surgery
Uterine Cervical Neoplasms / complications,  epidemiology*,  surgery
Grant Support
ID/Acronym/Agency:
KL2 TR000143/TR/NCATS NIH HHS; L30 AI075944/AI/NIAID NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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