Document Detail

Factors associated with pulmonary infarction. A discriminant analysis study.
MedLine Citation:
PMID:  4014073     Owner:  NLM     Status:  MEDLINE    
To determine the relative importance of multiple interrelated factors that have been considered to contribute to pulmonary infarction, the authors performed a discriminant analysis on consecutively autopsied patients with pulmonary embolism. From the clinic records of 45 individuals, the authors tabulated the underlying illness, history of valvular or ischemic heart disease, right and left ventricular failure, sepsis, shock, malignancy, premortem functional status, and the clinician's suspicion of pulmonary embolism. At postmortem examination, the authors measured and recorded the extent of emphysema, pneumonia, neoplasia, pulmonary vascular atherosclerosis; thickness and dilatation of both cardiac ventricles; the presence of valvular heart disease; the number, diameter, and amount of occlusion of the pulmonary arteries that contained thromboemboli; the extension of the clot, the size of the infarct; the Reid-Index; and the thickness of pulmonary and bronchial arterial wall. The major determinants of infarction were as follows: poor premortem functional status, the number of lobes having emboli, left ventricular failure, and the presence of lung cancer. The authors then tested the equation generated from these patients on 21 additional patients. The discriminant function correctly classified 81% of first group and predicted the occurrence of infarction in new patients with 70% accuracy. The size of the infarct was most correlated with the use of vasodilators and the embolic burden.
D E Schraufnagel; M S Tsao; Y T Yao; N S Wang
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of clinical pathology     Volume:  84     ISSN:  0002-9173     ISO Abbreviation:  Am. J. Clin. Pathol.     Publication Date:  1985 Jul 
Date Detail:
Created Date:  1985-08-07     Completed Date:  1985-08-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370470     Medline TA:  Am J Clin Pathol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15-8     Citation Subset:  AIM; IM    
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MeSH Terms
Analysis of Variance
Factor Analysis, Statistical
Heart Failure / complications
Lung Neoplasms / complications
Middle Aged
Pulmonary Artery / physiopathology*
Pulmonary Embolism / drug therapy,  etiology*,  pathology
Vasodilator Agents / therapeutic use
Reg. No./Substance:
0/Vasodilator Agents

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