| Factors associated with a prolonged QT interval in liver cirrhosis patients. | |
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MedLine Citation:
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PMID: 21146831 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: The aim of this study was to identify factors associated with prolonged QT interval in liver cirrhosis patients. MATERIALS AND METHODS: Thirty-eight patients with liver cirrhosis were enrolled in this study. The maximal QT interval (QTmax), heart rate-corrected QT interval (QTc), QT interval in lead DII (QTII), and mean QT interval (QTm) were determined manually, using 12-lead electrocardiogram. Additional laboratory tests were also performed. RESULTS: The following values were obtained: QTmax, 435 ± 43 milliseconds; QTc, 493 ± 46 milliseconds; QT interval in lead DII, 405 ± 46 milliseconds; and mean QT interval, 400 ± 40 milliseconds. Ten (6%) patients had a prolonged QTmax, and 27 (71%) had a prolonged QTc. The highest values were obtained for QTc and QTmax in patients with alcoholic cirrhosis and Child-Pugh class C, respectively. A moderate correlation was observed between QTmax and serum uric acid (URCA; r = 0.504), and multiple linear regression analysis revealed that URCA was significantly associated with QTc and heart rate. CONCLUSIONS: Liver disease severity, alcoholic etiology, and URCA are associated with prolonged QT interval in patients with liver cirrhosis. |
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Authors:
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Ioana Mozos; Camelia Costea; Corina Serban; Lelia Susan |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-10 |
Journal Detail:
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Title: Journal of electrocardiology Volume: - ISSN: 1532-8430 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Pathophysiology, University of Medicine and Pharmacy "Victor Babes," Timisoara, Romania. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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