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Factors associated with a prolonged QT interval in liver cirrhosis patients.
MedLine Citation:
PMID:  21146831     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: The aim of this study was to identify factors associated with prolonged QT interval in liver cirrhosis patients. MATERIALS AND METHODS: Thirty-eight patients with liver cirrhosis were enrolled in this study. The maximal QT interval (QTmax), heart rate-corrected QT interval (QTc), QT interval in lead DII (QTII), and mean QT interval (QTm) were determined manually, using 12-lead electrocardiogram. Additional laboratory tests were also performed. RESULTS: The following values were obtained: QTmax, 435 ± 43 milliseconds; QTc, 493 ± 46 milliseconds; QT interval in lead DII, 405 ± 46 milliseconds; and mean QT interval, 400 ± 40 milliseconds. Ten (6%) patients had a prolonged QTmax, and 27 (71%) had a prolonged QTc. The highest values were obtained for QTc and QTmax in patients with alcoholic cirrhosis and Child-Pugh class C, respectively. A moderate correlation was observed between QTmax and serum uric acid (URCA; r = 0.504), and multiple linear regression analysis revealed that URCA was significantly associated with QTc and heart rate. CONCLUSIONS: Liver disease severity, alcoholic etiology, and URCA are associated with prolonged QT interval in patients with liver cirrhosis.
Authors:
Ioana Mozos; Camelia Costea; Corina Serban; Lelia Susan
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-10
Journal Detail:
Title:  Journal of electrocardiology     Volume:  -     ISSN:  1532-8430     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
Affiliation:
Department of Pathophysiology, University of Medicine and Pharmacy "Victor Babes," Timisoara, Romania.
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