Document Detail

Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome.
MedLine Citation:
PMID:  19591989     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome. DESIGN: Historic cohort study. SETTING: Clinic-based data. PATIENT(S): The population included 214,219 ART cycles performed during 2004 to 2006 and reported to the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System Online database. The study population was limited to cycles of autologous, fresh embryo transfers to women without any treatment complications (212,041), and those developing moderate (1,523) or severe (655) OHSS. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Risk factors for developing OHSS, and its effect on achieving a pregnancy and live birth, as adjusted odds ratios. RESULT(S): Compared with white women, the risk of developing OHSS was increased for Black women (any OHSS, 1.88; severe OHSS, 2.93) and decreased for Hispanic women (any OHSS, 0.79). Ovarian hyperstimulation syndrome was associated with ovulation disorders (2.01), tubal factors (1.24), and unexplained factors (1.36). Ovarian hyperstimulation syndrome increased the odds of achieving a pregnancy (1.98 with any OHSS, 2.68 with severe), a live birth (any OHSS, 1.86), and a multiple live birth (1.58 with any OHSS, 1.86 with severe). The presence of any OHSS increased the risk of an adverse pregnancy outcome (stillbirth, low birthweight, or preterm birth) by 26% and low birthweight among singletons by 40%. CONCLUSION(S): Ovarian hyperstimulation syndrome is associated with a higher likelihood of pregnancy, and multiple gestations, but also greater risks for adverse pregnancy outcomes.
Barbara Luke; Morton B Brown; Dean E Morbeck; Susan B Hudson; Charles C Coddington; Judy E Stern
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2009-07-09
Journal Detail:
Title:  Fertility and sterility     Volume:  94     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-09-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1399-404     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Department of Obstetrics, Gynecology, and Reproductive Biology, Michigan State University, East Lansing, Michigan 48824, USA.
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MeSH Terms
Cohort Studies
Ethnic Groups / statistics & numerical data
Infant, Newborn
Live Birth / epidemiology
Ovarian Hyperstimulation Syndrome / complications*,  epidemiology,  ethnology,  etiology*
Pregnancy Outcome / epidemiology
Pregnancy Rate
Reproductive Techniques, Assisted* / adverse effects,  statistics & numerical data
Risk Factors
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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