| Factors associated with long-term oral hypoglycemic agent responsiveness in korean patients with type 2 diabetes mellitus. | |
| | |
MedLine Citation:
|
PMID: 21785749 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND: This study was performed to determine the factors associated with long-term oral hypoglycemic agent (OHA) responsiveness in Korean type 2 diabetic patients. METHODS: Two groups of patients were selected among the type 2 diabetic patients who were followed for more than two years at a university hospital diabetes clinic. The OHA responsive group consisted of 197 patients whose HbA1c levels were maintained at ≤7% with OHA for more than two years. The OHA failure group consisted of 180 patients whose HbA1c levels were >8% in spite of optimal combined OHA therapy or patients who required insulin therapy within the two years of the study. RESULTS: The OHA failure group had higher baseline values of fasting and postprandial glucose, HbA1c, and lower fasting, postprandial, and delta C-peptide compared to those of the OHA responsive group. The OHA failure group also had a higher proportion of female patients, longer diabetic duration, and more family history of diabetes. There were no significant differences in body mass index (BMI) or insulin resistance index between the two groups. Multiple logistic regression analysis showed that the highest quartile of baseline fasting, postprandial glucose, and HbA1c and the lowest quartile of postprandial and delta C-peptide were associated with an increased odds ratio of OHA failure after adjustment for age, sex, body mass index, and family history of diabetes. CONCLUSION: Lower baseline values of postprandial and delta C-peptide and elevated fasting glucose and HbA1c are associated with long-term OHA responsiveness in Korean patients with type 2 diabetes mellitus. |
| | |
Authors:
|
Bo-Yeon Kim; Chan-Hee Jung; Ji-Oh Mok; Chul-Hee Kim |
Related Documents
:
|
18572339 - Changes in the neuroendocrine control of energy homeostasis by adiposity signals during... 12851739 - Relationship between levels of insulin or triglycerides and serum concentrations of the... 18304569 - Performance of elisa for specific measurement of high-molecular-weight (hmw) adiponectin. 10754479 - Longitudinal changes of circadian leptin, insulin and cortisol plasma levels and their ... 15650029 - Adiponectin and other adipocytokines as predictors of markers of triglyceride-rich lipo... 9346919 - Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. 2444209 - Hepatic phosphoribosyl pyrophosphate concentration. regulation by the oxidative pentose... 7517749 - Neurotrophic effects of testosterone on the medial nucleus of the amygdala in adult mal... 659629 - Oral glucose augmentation of insulin secretion. interactions of gastric inhibitory poly... |
Publication Detail:
|
Type: Journal Article Date: 2011-06-30 |
Journal Detail:
|
Title: Diabetes & metabolism journal Volume: 35 ISSN: 2233-6087 ISO Abbreviation: Diabetes Metab J Publication Date: 2011 Jun |
Date Detail:
|
Created Date: 2011-07-25 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101556588 Medline TA: Diabetes Metab J Country: Korea (South) |
Other Details:
|
Languages: eng Pagination: 282-9 Citation Subset: - |
Affiliation:
|
Division of Endocrinology & Metabolism, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Small rice bowl-based meal plan for energy and marcronutrient intake in korean men with type 2 diabe...
Next Document: Retrospective analysis on the efficacy, safety and treatment failure group of sitagliptin for mean 1...