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Factors associated with elevated feno in infants with recurrent respiratory symptoms.
MedLine Citation:
PMID:  22743669     Owner:  NLM     Status:  Publisher    
Fraction of exhaled nitric oxide (FeNO) has been proposed as a non-invasive marker of eosinophilic bronchial inflammation in active asthma, supposed to reflect responsiveness to corticosteroid therapy. There are several factors influencing FeNO, and its role in early childhood respiratory disorders is still to be established.Between 2004 and 2008, 444 children aged <3 years with recurrent lower respiratory tract symptoms were referred to a tertiary centre for further investigation. 136 full-term, steroid-free, infection-free infants, median age of 16.4 months (range 4.0-26.7), successfully underwent measurement of FeNO, lung function tests, and a dosimetric methacholine challenge test.The median level of FeNO was 19.3 ppb (interquartile range 12.3-26.9 ppb). Elevated FeNO (≥27 ppb, the highest quartile) was associated with maternal history of asthma (adjusted odds ratio (OR) 3.2; 95% confidence interval (CI) 1.3-8.1; p=0.012), and increased airway responsiveness (the provocative dose of methacholine causing a 40% fall in maximal expiratory flow at functional residual capacity (PD40 V'max,FRC) ≤0.30 mg) (adjusted OR 4.1; 95% CI 1.4-12.7; p=0.012). Atopy, blood eosinophilia, and lung function were not associated with elevated FeNO.In conclusion, maternal history of asthma, and increased airway responsiveness are associated with elevated FeNO in infants with recurrent lower respiratory tract symptoms.
Anne Kotaniemi-Syrjänen; L Pekka Malmberg; Kristiina Malmström; Anna S Pelkonen; Mika J Mäkelä
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-27
Journal Detail:
Title:  The European respiratory journal : official journal of the European Society for Clinical Respiratory Physiology     Volume:  -     ISSN:  1399-3003     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Helsinki University Central Hospital, Helsinki, Finland.
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