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MedLine Citation:
PMID:  21546440     Owner:  NLM     Status:  Publisher    
ABSTRACT BACKGROUND: Previous studies have shown a high prevalence of bronchiectasis in patients with moderate-severe chronic obstructive pulmonary disease (COPD). However, the factors associated with bronchiectasis remain unknown in these patients. The objective of this study is to identify the factors associated with bronchiectasis in patients with moderate-severe COPD. METHODS: Consecutive moderate (50%<FEV(1)≤70%) or severe (FEV(1)≤50%) COPD patients were included prospectively. All subjects filled out a clinical questionnaire, including information about exacerbations. Peripheral blood samples were obtained and lung function tests were performed in all patients. Sputum samples were provided for monthly microbiological analysis for six months. All the tests were performed in a stable phase for at least six weeks. High-resolution CT scans of the chest were used to diagnose bronchiectasis. RESULTS: Ninety-two patients, 51 with severe COPD, were included. Bronchiectasis was present in 53 patients (57.6%). The variables independently associated with the presence of bronchiectasis were severe airflow obstruction (OR 3.87; CI95%: 1.38-10.5; p=0.001); isolation of a potentially pathogenic microorganism (PPM) (OR 3.59; CI95%: 1.3-9.9; p=0.014) and at least one hospital admission due to COPD exacerbations in the previous year (OR 3.07; CI95%: 1.07-8.77; p=0.037). CONCLUSION: We found an elevated prevalence of bronchiectasis in patients with moderate-severe COPD and this was associated with severe airflow obstruction, isolation of a PPM from sputum and at least one hospital admission for exacerbations in the previous year.
Miguel Ángel Martínez-García; Juan José Soler-Cataluña; Yolanda Donat-Sanz; Pablo Catalán-Serra; Marcos Agramunt-Lerma; Javier Ballestín-Vicente; Miguel Perpiñá-Tordera
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-5
Journal Detail:
Title:  Chest     Volume:  -     ISSN:  1931-3543     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Pneumology Unit*.
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