| FACTORS ASSOCIATED WITH BRONCHIECTASIS IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE PATIENTS. | |
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MedLine Citation:
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PMID: 21546440 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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ABSTRACT BACKGROUND: Previous studies have shown a high prevalence of bronchiectasis in patients with moderate-severe chronic obstructive pulmonary disease (COPD). However, the factors associated with bronchiectasis remain unknown in these patients. The objective of this study is to identify the factors associated with bronchiectasis in patients with moderate-severe COPD. METHODS: Consecutive moderate (50%<FEV(1)≤70%) or severe (FEV(1)≤50%) COPD patients were included prospectively. All subjects filled out a clinical questionnaire, including information about exacerbations. Peripheral blood samples were obtained and lung function tests were performed in all patients. Sputum samples were provided for monthly microbiological analysis for six months. All the tests were performed in a stable phase for at least six weeks. High-resolution CT scans of the chest were used to diagnose bronchiectasis. RESULTS: Ninety-two patients, 51 with severe COPD, were included. Bronchiectasis was present in 53 patients (57.6%). The variables independently associated with the presence of bronchiectasis were severe airflow obstruction (OR 3.87; CI95%: 1.38-10.5; p=0.001); isolation of a potentially pathogenic microorganism (PPM) (OR 3.59; CI95%: 1.3-9.9; p=0.014) and at least one hospital admission due to COPD exacerbations in the previous year (OR 3.07; CI95%: 1.07-8.77; p=0.037). CONCLUSION: We found an elevated prevalence of bronchiectasis in patients with moderate-severe COPD and this was associated with severe airflow obstruction, isolation of a PPM from sputum and at least one hospital admission for exacerbations in the previous year. |
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Authors:
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Miguel Ángel Martínez-García; Juan José Soler-Cataluña; Yolanda Donat-Sanz; Pablo Catalán-Serra; Marcos Agramunt-Lerma; Javier Ballestín-Vicente; Miguel Perpiñá-Tordera |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-5-5 |
Journal Detail:
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Title: Chest Volume: - ISSN: 1931-3543 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-5-6 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0231335 Medline TA: Chest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Pneumology Unit*. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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