| Factors associated with age of onset of necrotizing enterocolitis. | |
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MedLine Citation:
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PMID: 2789545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To investigate factors associated with risk and age of onset for necrotizing enterocolitis (NEC), a retrospective case-control review was performed of patients with NEC and control infants matched for birthweight and date of admission. NEC cases were defined by Bell staging criteria and were included if pneumatosis intestinalis, histologic confirmation, or a recognized complication of NEC was identified in association with clinical signs and symptoms. NEC was significantly related to birthweight and premature post-conceptional age. In contrast to control infants, patients with NEC had higher 5 minute Apgar scores, less significant respiratory disease, and more rapid feeding practices. Two distinct subgroups of patients with NEC based on postnatal age of onset were apparent. Patients with early onset NEC (21 days or less postnatal age) had less significant respiratory disease and were fed more rapidly than late onset patients. Late onset NEC (more than 21 days postnatal age) occurred frequently in convalescing, relatively well premature infants who were still, however, of preterm postconceptional age. Relatively well premature infants with minimal respiratory disease are still at risk for NEC. Advances in neonatal care and survival of very low birthweight infants may account for a shift in prevalence to older infants who are yet of preterm postconceptional age. |
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Authors:
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R F Covert; J Neu; M J Elliott; J L Rea; P A Gimotty |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: American journal of perinatology Volume: 6 ISSN: 0735-1631 ISO Abbreviation: Am J Perinatol Publication Date: 1989 Oct |
Date Detail:
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Created Date: 1989-11-07 Completed Date: 1989-11-07 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8405212 Medline TA: Am J Perinatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 455-60 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, University of Florida College of Medicine, Gainesville. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Age Factors Birth Weight Case-Control Studies Enterocolitis, Pseudomembranous / complications, epidemiology* Humans Infant Infant, Low Birth Weight* Infant, Newborn Infant, Premature, Diseases / epidemiology* Pneumatosis Cystoides Intestinalis / complications Respiration Disorders / complications Retrospective Studies Risk Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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