Document Detail

Factors associated with adherence to chemotherapy guidelines in patients with non-small cell lung cancer.
MedLine Citation:
PMID:  21816502     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Evidence-based guidelines recommend chemotherapy for medically fit patients with stages II-IV non-small cell lung cancer (NSCLC). Adherence to chemotherapy guidelines has rarely been studied among large populations, mainly because performance status (PS), a key component in assessing chemotherapy appropriateness, is missing from claims-based datasets. Among a large cohort of patients with known PS, we describe first line chemotherapy use relative to guideline recommendations and identify patient factors associated with guideline concordant use.
PATIENTS AND METHODS: Insured patients, ages 50+, with stages II-IV NSCLC between 2000 and 2007 were identified via tumor registry (n=406). Chart abstracted PS, automated medical claims, Census tract information, and travel distance were linked to tumor registry data. Chemotherapy was considered appropriate for patients with PS 0-2. Multivariate logit models were fit to evaluate patient characteristics associated with chemotherapy over- and under-use per guideline recommendations. Tests of statistical significance were two sided.
RESULTS: Overall compliance with first line chemotherapy guidelines was 71%. Significant (p<0.05) predictors of chemotherapy underuse (19%) included increasing age (odds ratio [OR], 1.09), higher income (OR, 1.02), diagnosed before 2003 (OR, 2.05), and vehicle access (OR, 6.96) in the patient's neighborhood. Significant predictors of chemotherapy overuse (10%) included decreasing age (OR, 0.92), diagnosed after 2003 (OR, 3.24), and higher income (OR, 1.05) in the patient's neighborhood. Among NSCLC patients 29% do not receive guideline recommended chemotherapy treatment missing opportunities for cure or beneficial palliation, or receiving chemotherapy with more risk of harm than benefit. Care concordant with guidelines is influenced by age, economic considerations such as income and transportation barriers.
Ramzi G Salloum; Thomas J Smith; Gail A Jensen; Jennifer Elston Lafata
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-08-03
Journal Detail:
Title:  Lung cancer (Amsterdam, Netherlands)     Volume:  75     ISSN:  1872-8332     ISO Abbreviation:  Lung Cancer     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-10     Completed Date:  2012-04-24     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  8800805     Medline TA:  Lung Cancer     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  255-60     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
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MeSH Terms
Carcinoma, Non-Small-Cell Lung / drug therapy*
Guideline Adherence*
Lung Neoplasms / drug therapy*
Medication Adherence*
Middle Aged
Practice Guidelines as Topic
Grant Support
R01 CA114204/CA/NCI NIH HHS; R01 CA114204-03/CA/NCI NIH HHS; R01 CA114204-03/CA/NCI NIH HHS

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