Document Detail

Factors affecting renal scar development in children with spina bifida.
MedLine Citation:
PMID:  17851282     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIMS: Prevention of renal scarring is the main therapeutic goal in children with spina bifida. We aimed to determine factors affecting renal scar development in these patients. MATERIALS AND METHODS: Records of 312 children admitted between 1994 and 2005 with spina bifida were reviewed. Age on admission, gender, presence of previous febrile urinary tract infections (UTIs), vesicoureteral reflux (VUR), and initial urodynamic findings were noted. Patients were grouped regarding presence/absence of renal scars on DMSA scans. Chi2 and Student's t tests were used for statistical evaluation. RESULTS: Seventy-two patients had renal scars on admission. Mean age was 4.62 +/- 4.59 years for patients without renal scars and 6.35 +/- 4.9 years for patients with scars. Male/female ratio was 1:1 in the scarless group and 1:2 in the group with scars. Previous febrile UTI was present in 11 of 240 scarless patients in contrast to 7 out of 72 patients in the scar group (p > 0.05). VUR was present in only 16.3% of cases without scars, whereas 36.1% of patients in the scar group had VUR. Detrusor overactivity and detrusor sphincter dyssynergia were observed in 67.1% of scarred patients, whereas this figure was 42.4% in the scarless group. The comparison of age on admission, gender, detrusor overactivity, and detrusor sphincter dyssynergia revealed significant differences between patients with and without renal scars. CONCLUSIONS: Late referral, female gender, overactive detrusor, and detrusor sphincter dyssynergia have detrimental effects on renal parenchymal function in spina bifida patients. Patient selection for aggressive treatment using these features may prevent renal parenchymal deterioration.
S K Ozel; Z Dokumcu; C Akyildiz; A Avanoglu; I Ulman
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Urologia internationalis     Volume:  79     ISSN:  1423-0399     ISO Abbreviation:  Urol. Int.     Publication Date:  2007  
Date Detail:
Created Date:  2007-09-13     Completed Date:  2007-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417373     Medline TA:  Urol Int     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  133-6     Citation Subset:  IM    
Copyright Information:
2007 S. Karger AG, Basel
Department of PediatricUrology, Ege University Faculty of Medicine, Izmir, Turkey.
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MeSH Terms
Child, Preschool
Cicatrix / etiology*,  prevention & control
Kidney Diseases / etiology*,  physiopathology,  prevention & control
Predictive Value of Tests
Retrospective Studies
Sex Factors
Spinal Dysraphism / complications*
Urinary Tract Infections / etiology
Vesico-Ureteral Reflux / etiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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