| Factors affecting peak bone density in Japanese women. | |
| | |
MedLine Citation:
|
PMID: 9914316 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Both genetic and environmental factors have been shown to contribute to the determination of bone density. To clarify the interaction between genetic and environmental factors affecting peak bone mass, we investigated the correlation between bone mineral density (BMD) and physical constitution, vitamin D receptor (VDR) genotype, age, age of menarche, history of menstrual dysfunction, and exercise in 157 healthy young Japanese women. History of exercise and menstrual dysfunction were significant independent predictors of BMD. The VDR genotype also affects peak bone density. Exercise has been shown to increase BMD in a similar way for each VDR genotype including those women who have the particular genotype associated with low bone density. This data indicate that there are complex gene-environmental interactions particularly in relation to menstrual history, exercise, and genetic factors during childhood/adolescence that may have implications for the development of adult BMD in women. |
| | |
Authors:
|
Y Fujita; K Katsumata; A Unno; T Tawa; A Tokita |
Related Documents
:
|
6430516 - Skeletal calcium homeostasis and countermeasures to prevent disuse osteoporosis. 20727126 - The influence of long-term treadmill exercise on bone mass and articular cartilage in o... 17103296 - A multi-component exercise regimen to prevent functional decline and bone fragility in ... 18333526 - Role of exercise in osteoporosis prevention--current concepts. 20464166 - Electromyographic analyses of muscle pre-activation induced by single joint exercise. 19801136 - Exercise and end-stage kidney disease: functional exercise capacity and cardiovascular ... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Calcified tissue international Volume: 64 ISSN: 0171-967X ISO Abbreviation: Calcif. Tissue Int. Publication Date: 1999 Feb |
Date Detail:
|
Created Date: 1999-03-18 Completed Date: 1999-03-18 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 7905481 Medline TA: Calcif Tissue Int Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 107-11 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, Juntendo University School of Medicine, 3-1-3, Hongo, Bunkyo-ku, Tokyo 113, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Alcohol Drinking Bone Density / physiology* Exercise Female Genotype Humans Japan Menstrual Cycle Receptors, Calcitriol / genetics* Smoking |
| Chemical | |
Reg. No./Substance:
|
0/Receptors, Calcitriol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Early and late postmenopausal bone loss is associated with BsmI vitamin D receptor gene polymorphism...
Next Document: Effect of lifetime occupational physical activity on indices of bone mineral status in healthy postm...