Document Detail

Factors affecting left ventricular function after correction of tetralogy of Fallot.
MedLine Citation:
PMID:  6498030     Owner:  NLM     Status:  MEDLINE    
To investigate the possible causes of left ventricular dysfunction after total correction of tetralogy of Fallot, 84 patients, aged 1 1/2 to 16 years, were studied by left ventricular cineangiography both before and a mean of 4.6 months after operation. Left ventricular ejection fraction and mean velocity of circumferential fibre shortening were calculated; using multivariate analysis the results were correlated with age at operation, the degree of hypoxia and polycythaemia before operation, occurrence of hypoxic spells, and the duration of operative procedures (cardiopulmonary bypass and aortic cross clamping). The postoperative left ventricular ejection fraction was decreased slightly or moderately in 46% of patients. The variable most significantly associated with altered left ventricular function was a history of hypoxic spells. Age, the degree of chronic hypoxia, and polycythaemia did not correlate significantly with left ventricular function indices. Although no correlation was found between the duration of cardiopulmonary bypass and left ventricular ejection fraction, bypass times exceeding 120 minutes were associated with decreased ejection fractions; this was statistically significant and independent of the variable "hypoxic spells". Thus repeated episodes of acute hypoxia and long operative procedures appear to have a deleterious effect on left ventricular function in tetralogy of Fallot.
M de Lorgeril; B Friedli; A Assimacopoulos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British heart journal     Volume:  52     ISSN:  0007-0769     ISO Abbreviation:  Br Heart J     Publication Date:  1984 Nov 
Date Detail:
Created Date:  1984-12-27     Completed Date:  1984-12-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0370634     Medline TA:  Br Heart J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  536-41     Citation Subset:  AIM; IM    
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MeSH Terms
Anoxia / complications
Cardiopulmonary Bypass
Child, Preschool
Heart / physiopathology*
Heart Catheterization
Heart Ventricles / physiopathology
Postoperative Complications / etiology
Stroke Volume
Tetralogy of Fallot / physiopathology,  radiography,  surgery*
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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