Document Detail

Factors affecting iron stores in infants 4-18 months of age.
MedLine Citation:
PMID:  11248874     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To determine the effects of dietary, physiological or environmental factors on body iron levels in infants aged 4-18 months. DESIGN: The daily iron intake of the infants was measured from a diet history obtained by interview using a standardised question sheet, previously validated against weighed intake (minimum 3 days) in an independent sample of 8 and 18 month old infants. Capillary blood samples were analyzed for haemoglobin, mean cell volume, haematocrit, zinc protoporphyrin and plasma ferritin concentration. Ferritin values were log-transformed prior to analysis to give a better approximation to the normal distribution and forward stepwise multiple linear regression was carried out using SPSS. SETTING: The city of Norwich, UK and some of its suburbs. SUBJECTS: One hundred and eighty-one healthy infants in age groups 4, 8, 12 and 18 months. RESULTS: Main determinants of iron stores in the 4 month old infants were birth weight (+ve (P < 0.001)) and body weight (-ve (P < 0.005)). In the 8 month old infants intake of cow's milk (-ve (P < 0.05)), belonging to a smoking household (-ve (P < 0.05)) and quantity of commercial babyfood consumed (+ve (P < 0.05)) were significant. In this age group there was a gender effect (girls > boys (P < 0.01)) and the gender effect remained at 12 months (girls > boys (P < 0.05)), but at 18 months only non-haem iron intake was a significant factor (-ve (P < 0.05)). CONCLUSIONS: At 4 months of age birth weight and body weight exert the greatest influence on iron stores, whereas by 8 months components of the weaning diet have an effect (commercial babyfood (+ve), cow's milk (-ve)); there is also a gender effect (girls > boys), possibly reflecting the different growth rate between boys and girls. At 12 and 18 months the only significant factors are gender (girls > boys) and non-haem iron intake (-ve) respectively.
S G Wharf; T E Fox; S J Fairweather-Tait; J D Cook
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical nutrition     Volume:  51     ISSN:  0954-3007     ISO Abbreviation:  Eur J Clin Nutr     Publication Date:  1997 Aug 
Date Detail:
Created Date:  2001-03-15     Completed Date:  2001-06-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8804070     Medline TA:  Eur J Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  504-9     Citation Subset:  IM    
Institute of Food Research, Norwich Research Park, Colney, Norwich, NR4 7UA, Norfolk, UK.
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MeSH Terms
Age Factors
Birth Weight
Body Weight
Erythrocyte Indices
Ferritins / blood*
Hemoglobins / analysis,  metabolism*
Infant Food*
Infant Nutritional Physiological Phenomena*
Iron / analysis,  blood*
Iron, Dietary / administration & dosage*
Milk / adverse effects
Nutritional Status
Regression Analysis
Sex Factors
Reg. No./Substance:
0/Hemoglobins; 0/Iron, Dietary; 7439-89-6/Iron; 9007-73-2/Ferritins

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