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Factors affecting impairment of blood rheology in obese subjects.
MedLine Citation:
PMID:  22884686     Owner:  NLM     Status:  Publisher    
OBJECTIVES: Impairment of blood rheology has been reported to be associated with cardiovascular diseases. Recently, visible micro channel methods [micro channel array flow analyzer (MC-FAN)] have been developed to clinically evaluate blood rheology. The aim of this cross-sectional study is to clarify the factors important for impairment of blood rheology in obese subjects using MC-FAN. METHODS: One hundred and fifty-nine obese subjects and 100 non-obese subjects with no history of cardiovascular diseases were enrolled. Blood passage time (BPT) was measured using MC-FAN and relationships between BPT and various clinical parameters were examined. RESULTS: BPT was significantly higher in obese subjects than in non-obese subjects (obesity vs. non-obesity: 62.8±17.9s vs. 54.1±14.6s, p<0.001); however, there were no significant relationships between BPT and body mass index or waist circumference in obese subjects. BPT was significantly related to systolic blood pressure levels (r=0.21; p<0.001), high-sensitivity C-reactive protein concentrations (r=0.37; p<0.001), a marker of inflammation, and derivatives of reactive oxygen metabolites test (r=0.38; p<0.001), a marker of oxidative stress, smoking, and exercise habits in obese subjects. Furthermore, multivariate analysis revealed that derivatives of reactive oxygen metabolites test (t=5.2; p<0.001), high sensitivity C-reactive protein concentration (t=3.6; p<0.01), smoking (t=3.2; p<0.001), and exercise habits (t=-2.4; p<0.05) were independent variables for BPT. CONCLUSION: Data indicate that inflammation, oxidative stress, and lifestyle choices are more important factors for impairment of blood rheology, which is evaluated by MC-FAN, than the degree of adiposity in obese subjects.
Takashi Hitsumoto
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-9
Journal Detail:
Title:  Journal of cardiology     Volume:  -     ISSN:  1876-4738     ISO Abbreviation:  J Cardiol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8804703     Medline TA:  J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved.
Hitsumoto Medical Clinic, Shimonoseki, Japan.
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